Discover and read the best of Twitter Threads about #tumorigenesis
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1/12 Check our latest work led by our Postdoc @fbonnay_vienna where we describe a fundamental role of mitochondrial fusion and oxidative metabolism for tumor cell immortalization, in the larval brain of #Drosophila melanogaster. sciencedirect.com/science/articl… 
2/12 Our tumor model of choice is derived from asymmetrically dividing neural stem cells (NSCs) called type II Neuroblasts, deficient for the tumor suppressor gene brain tumor or brat. brat-deficient type II Neuroblasts give rise to big and lethal brain tumors.
3/12 We first observed that brat tumors have increased oxidative metabolism compared to normal brains, with increased oxygen consumption and TriCarboxylic Acid (TCA) cycle metabolites.
