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Going to attempt a twitter space tomorrow with some cardiologists at noon to discuss a non-COVID cardiology topic.
#twitterheartspaces
We'll be discussing re-analysis of the data used to approve a common injectable medicine to lower cholesterol levels -- Evolucumab
#twitterheartspaces
We'll be discussing re-analysis of the data used to approve a common injectable medicine to lower cholesterol levels -- Evolucumab
Evolucumab was shown to markedly lower LDL in patients who already had very low LDL levels to begin with.
The real question is whether it also lowered an endpoint that matters to patients like fewer heart attacks, fewer stents, or dying less..
The real question is whether it also lowered an endpoint that matters to patients like fewer heart attacks, fewer stents, or dying less..
The FOURIER primary endpoint was a composite of : (cardiovascular death, MI, stroke, unstable angina, or need for a stent/bypass) and reduced this endpoint by 1.5% (1344/13784 in the evolocumab arm vs 1563/13780 in the placebo arm)
This lead to FDA approval..
This lead to FDA approval..
