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Tonight our clinical article in #EmoryID journal club is being discussed by @Boghuma
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Clinical Metagenomic Sequencing for Diagnosis of Meningitis and Encephalitis | NEJM nejm.org/doi/full/10.10…
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Clinical Metagenomic Sequencing for Diagnosis of Meningitis and Encephalitis | NEJM nejm.org/doi/full/10.10…
Of 204 cases, there were 13 cases where a pathogen was identified by metagenomic sequencing alone, and 7 of those results changed management.
Small yield for applying this technology to such a large sample of patients, especially since metagenomic sequencing alone missed 26 pathogens detected by routine tests.
#EmoryID discussing this article at #TwitterIDJC tonight
Wish @CarlosdelRio7 was here to join in with the tweeting
Epidemic of carbapenem-resistant Klebsiella pneumoniae in Europe is driven by nosocomial spread | Nature Microbiology nature.com/articles/s4156…
Wish @CarlosdelRio7 was here to join in with the tweeting
Epidemic of carbapenem-resistant Klebsiella pneumoniae in Europe is driven by nosocomial spread | Nature Microbiology nature.com/articles/s4156…
As compared to other resistance mechanisms for Klebsiella pneumoniae, strains with carbapenamases were more likely to have their “genetic nearest neighbor” within the same hospital, suggesting they are more likely spread within single hospitals.
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Over half of the hospitals that submitted isolates likely had within-hospital transmission
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#EmoryID Journal Club today discussing a basic science article on heteroresistance nature.com/articles/s4156…. Be sure to join us at 7:30 pm for a #TwitterIDJC @CarlosdelRio7 @Armstrws @JessH_A @MikeWoodworthMD @janecyoon
The authors estimate that 27.4% of their isolates could exhibit heteroresistance? Do you believe this estimate? Does it surprise you?
Do you think we should be testing for heteroresistance on all cultures? Would you use Etests to screen for this?
