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Why don't trauma patients' platelets work?

Because they're attacked by histones and explode into these (never seen before) balloons (red arrows) that don't aggregate but support thrombin generation!

ncbi.nlm.nih.gov/pubmed/31405966
Good to have this fantastic work finally in print in @PNASNews after several years of hard graft by @CommsC4TS, especially @Miss_GPie and @Paulvulliamy.
@PNASNews @CommsC4TS @Miss_GPie @Paulvulliamy We went looking for why trauma patients' platelets show a global non-responsiveness to all aggregatory stimuli, but appear to increase their contribution to clot formation on ROTEM. Weird!!?!
Read 10 tweets
FIRST UP: #1 seed Pygmy Hippo (Choeropsis liberiensis) vs. #9 seed Maned Rat (Lophiomys imhausi)!! #2018MMM
In round 1, the pygmy hippo inadvently stabbed a wandering star-nosed mole with its tusk in a swamp #oops #mybad #2018MMM
While the maned rat dared the platypus to fight over a burrow #ComeAtMeBro but the monotreme, lacking his venom, wisely passed on the encounter #2018MMM
Read 18 tweets
1\ A thought experiment: The year is 2277. You're the bartender at a spaceport in a faraway Earth colony on a planet orbiting α-Centauri: a distance of ~4 light years. Guy walks into your bar, slams down a credit chit, and asks for a drink.

How do you know his money is any good?
2\ If the credit chit were guaranteed by a bank or a blockchain or something local to α-Centauri it'd be easy, just like it is here on Earth in 2018.

But say this guy is fresh-thawed after his long journey from Earth aboard a lighthugger. What kind of wealth could he even have?
3\ He's unlikely to be carrying base metals. Like natural resources, they'd still be valuable, but too heavy to transport from Earth. Physical fiat (bank notes) wouldn't be accepted either: too easy to 3D-print forgeries.

So what form of wealth survives interstellar voyages?
Read 17 tweets

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