Discover and read the best of Twitter Threads about #worldsepsisday
Most recents (3)
Die vor 20 Jahren publizierte "Rivers"Studie hat die #Sepsis Therapie grundlegend verändert. Sie definierte Therapieziele, die innerhalb von 6h erreicht werden sollten. Sie zeigte eine Mortalitätssenkung von 46,5 auf 30,5% (1/4)
nejm.org/doi/10.1056/NE…
nejm.org/doi/10.1056/NE…
In den letzten Jahren wurden die Parameter angepasst, der zentrale Venendruck spielt z.B. keine große Rolle mehr, ebenso wird die großzügige Flüssigkeitsgabe zunehmend kritisch gesehen. Die Indikation zur schnellen Bluttransfusion wurde ebenfalls revidiert. (2/4)
Warum also bahnbrechend? Die Studie hat die #Sepsis als einen zeitkritischen medizinischen Notfall behandelt. So schwer nachvollziehbar das heute ist, davor war das nicht immer der Fall. Die #SurvivingSepsisCampaign wurde gegründet, mit dem Ziel, die Mortalität zu senken. (3/4)
Today is #WorldSepsisDay
Q: What is #sepsis?
A: Sepsis is a life-threatening medical emergency. It occurs when a person has an infection, and the body’s response causes injury to its own tissues and organs.
Sepsis affects millions of patients 🌍
bit.ly/2X12EN2
Q: What is #sepsis?
A: Sepsis is a life-threatening medical emergency. It occurs when a person has an infection, and the body’s response causes injury to its own tissues and organs.
Sepsis affects millions of patients 🌍
bit.ly/2X12EN2
#Sepsis is estimated to kill 1⃣1⃣ million people each year, including almost 3⃣ million young children. It disables millions more.
who.int/news-room/fact…
who.int/news-room/fact…
Anyone with an infection can develop #sepsis, but some people are more at risk than others:
🔸Pregnant women
🔸Newborns
🔸The elderly
🔸People with chronic diseases or immunosuppression
🔸Hospitalized patients
bit.ly/2X12EN2
🔸Pregnant women
🔸Newborns
🔸The elderly
🔸People with chronic diseases or immunosuppression
🔸Hospitalized patients
bit.ly/2X12EN2
#WorldSepsisDay
Time to move on from
"WHEN TO PRESCRIBE ANTIBIOTICS"
to
"WHEN TO RESIST THE TEMPTATION TO PRESCRIBE ANTIBIOTICS AND BE SAFE FOR THE PATIENT".
1/6
In most patients with exception of Septic Shock, we can wait for real evidence of infection and possible source.
Time to move on from
"WHEN TO PRESCRIBE ANTIBIOTICS"
to
"WHEN TO RESIST THE TEMPTATION TO PRESCRIBE ANTIBIOTICS AND BE SAFE FOR THE PATIENT".
1/6
In most patients with exception of Septic Shock, we can wait for real evidence of infection and possible source.
2/6
ED patients with LRTI and low suspicion of Bacterial Infection, it is reasonably safe to hold ABX if baseline PCT <0.25.
For additional safety, repeat PCT after 6-12 Hours for any rise.
In countries with high baseline antibiotic consumption, it can reduce ABX exposure.
ED patients with LRTI and low suspicion of Bacterial Infection, it is reasonably safe to hold ABX if baseline PCT <0.25.
For additional safety, repeat PCT after 6-12 Hours for any rise.
In countries with high baseline antibiotic consumption, it can reduce ABX exposure.
3/6
A low PCT value in appropriate clinical context is useful even in ICU patients to safely hold ABX.
Especially so in countries with high exposure to antibiotics.
PCT should not be used to escalate ABX [Jansen J U et al. Crit Care Med. 2011; 39:2048 –58].
A low PCT value in appropriate clinical context is useful even in ICU patients to safely hold ABX.
Especially so in countries with high exposure to antibiotics.
PCT should not be used to escalate ABX [Jansen J U et al. Crit Care Med. 2011; 39:2048 –58].
