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What are the #histopathology image #WSI patterns associated with gene expression in cancer? Can we discover them with #AI and use them for spatial profiling and #precision medicine?
Our preprint explores limitations & possibilities of #cpath for this.
biorxiv.org/content/10.110…
Our preprint explores limitations & possibilities of #cpath for this.
biorxiv.org/content/10.110…
Existing methods aim to predict expression of individual genes from #WSIs but ignore any inter-dependencies in expression across genes. We show that it is typically not possible to predict expression of a single gene due to such codependencies as shown in fig for a group of genes
To formalize this, we first used mutual information to identify groups of genes whose expression in breast cancer patients are significantly inter-dependent and form the basis of important cancer and biological pathways and can be used for precision medicine.
