Discover and read the best of Twitter Threads about #y144del

Most recents (2)

BREAKING🔔 We introduce the latest work from G2P-Japan🇯🇵 focusing on the virological characteristics of new SARS-CoV-2 lineage of concern, XBB.1.5 (aka #Kraken), which is rapidly spreading in the US🇺🇸 Please RT! Preprint/peer-review paper will come soon🔥 1/
XBB.1.5 = XBB.1 + #F486P in spike. We also found that a part of XBB.1.5 has reversion mutation in Y144del (=XBB.1.5 + #ins144Y) in spike. Because #Y144del evades antiviral immunity and decreases pseudovirus infectivity, its reversion might be also critical. 2/
First, a brilliant young talent, @jampei2, showed that the relative basic reproduction number (Re) of XBB.1.5 is >1.2-fold greater than the parental XBB.1 (❗️). Importantly the "1.2-fold difference" is similar to the differences between BA.1 versus BA.2 and BA.2 versus BA.5. 3/
Read 7 tweets
#拡散希望 速報🔔 G2P-Japan🇯🇵の最新作「オミクロン亜株XBB.1.5の性状解析」を、論文/プレプリント公開前に速報します(図はメイキング)。本研究では、流行拡大中の#オミクロン XBB.1.5株(通称 #クラーケン)の性質を解明しました🔥 1/
2022年末にアメリカ🇺🇸で突如感染爆発を始めたのがXBB.1.5株です。この株は、↓で我々が報告しているXBB.1株(G2P-Japan🇯🇵プレプリント第15弾)が、スパイクに #F486P という変異を獲得したものです。2/
それに加え、XBB系統が持っていた #Y144del という欠損が復帰したXBB.1.5株(XBB.1.5+ins144Y)も確認されています。Y144del という変異は、ブレイクスルー血清への抵抗性の上昇と、ウイルスの感染力の減少に作用する変異です(G2P-Japan🇯🇵プレプリント第15弾より)。3/
Read 10 tweets

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