Discover and read the best of Twitter Threads about #zonulin

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Multisystem inflammatory syndrome in children is driven by zonulin-dependent loss of gut mucosal barrier.. @vipintukur @ProfSomashekhar @naveenthacker @iapindia @INDIANJOURNALO4 @VirusesImmunity @EditorIndPed @ICMRDELHI @MoHFW_INDIA @iiscbangalore Image
Weeks after #SARS-CoV-2 inf or exposure, some children develop a severe, life-threatening illness called Multisystem Inflammatory Syndrome in Children (#MIS-C). GI symptoms are common in MIS-C pts & severe hyperinflammatory response ensues with potential for โค๏ธ complications.
๐Ÿ‘‰๐ŸฝAs proof of concept, they treated a #MIS-C patient with #larazotide, a #zonulin antagonist, & monitored impact on antigenemia and clinical response.
๐Ÿ‘‰๐Ÿฝin MIS-C, prolonged + of SARS-CoV-2 in t GI tract โžก๏ธ to release of zonulin, a biomarker of intestinal permeability,
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