This is on my reading list for this week
📌 Not all elevations in serum creatinine portend bad outcomes‼️
#Nephpearls #NephSAP #AKIinICU
👉🏼 asn-online.org/api/download/h…
At the current time, there is no consensus regarding the role of early initiation of RRT and its impact on patient outcomes in the setting of AKI
👉🏼 Awaiting ⏳ 👉🏼 STARRT-AKI trial
#Nephpearls #NephSAP
👉 slideplayer.com/slide/8918419/…
.@goKDIGO Clinical Practice Guidelines for AKI recommend that during CRRT a minimum effluent flow of 20 to 25 ml/kg per hour should be provided
#Nephpearls #NephSAP
👉🏼 kdigo.org/wp-content/upl…
Components of the @goKDIGO care bundle
#Nephpearls #NephSAP
👉🏼 nature.com/articles/nrnep…
Furosemide Stress Test
#Nephpearls #NephSAP
👉🏼 karger.com/Article/Pdf/44…
The presence of significant proteinuria prior to the onset of dialysis requiring AKI decreases the chances of renal recovery
#Nephpearls #NephSAP
👉🏼 ncbi.nlm.nih.gov/m/pubmed/29352…
Renal Functional Reserve
📌 The difference between the stress (peak) GFR achieved by stimulation & the baseline GFR
📌 Identifies the capacity of the kidney to compensate or increase its function in states of demand or disease
#Nephpearls #NephSAP
👉🏼 karger.com/Article/Pdf/36…
Renal Functional Reserve and Renal Recovery after AKI ca. 2014
#Nephpearls #NephSAP
👉🏼 karger.com/Article/Pdf/36…
Renal functional reserve testing can identify at-risk individuals for postoperative AKI
#Nephpearls #NephSAP
👉🏼 annalsthoracicsurgery.org/article/S0003-…
AKI Risk Prediction Score ca. 2017 from @astute_kidney @MacedoEtienne @NDTsocial
#Nephpearls #NephSAP
👉🏼 academic.oup.com/ndt/article/32…
Electronic AKI alerts and care decision support systems improve patient out- comes in the setting of clinical AKI
#Nephpearls #NephSAP
👉🏼 cjasn.asnjournals.org/content/clinja…
Balanced solutions appear to minimally decrease the risk of major adverse kidney events in critically ill ICU patients and emergency room patients
#Nephpearls #NephSAP
Drug-induced AKI phenotypes from @jaykoyner @CharuThakar
#Nephpearls #NephSAP
PERAZELLA: Drug-induced AKI can occur at multiple sites along the nephron
#NKFClinicals 🇺🇸 #Nephpearls
👉🏼 cjasn.asnjournals.org/content/clinja…
PERAZELLA: Drug-induced AKI
📌 Kidney specific factors
📌 Drug specific factors
📌 Patient specific factors
#NKFClinicals 🇺🇸 #Nephpearls
👉🏼 cjasn.asnjournals.org/content/clinja…
PRESERVE Trial: NaHCO3 ➕ Acetylcysteine ~ NO significant difference across groups in death, need for dialysis or >/= 50% increase in creatinine at 90 days
#Nephpearls #NephSAP
#VisualAbstract from @NEJM
👉🏼 nejm.org/doi/pdf/10.105…
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