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Edgar V. Lerma 🇵🇭 Profile picture
Edgar V. Lerma 🇵🇭
@edgarvlermamd
Chicago Sports Fan... Nephrologist by day. My tweets are not medical advice. The views expressed here are my own and not those of my employer.
20 subscribers
Feb 26, 2022 • 9 tweets • 9 min read
Advancing Evidence-Based Care in Diabetes and CKD
#ISNWCN 🇲🇾 #Nephpearls

👉 kdigo.org/wp-content/upl… Holistic approach for improving outcomes in patients with Diabetes and CKD
#ISNWCN 🇲🇾 #Nephpearls
Feb 26, 2022 • 13 tweets • 17 min read
.@goKDIGO Glomerular Diseases Guideline: Reflections on a Decade of Progress with @adrianliew8 @ReichHeather @Dr_KeishaGibson
#ISNWCN 🇲🇾 #Nephpearls

👉 kdigo.org/wp-content/upl… IgA Nephropathy: A 1st step is in treating IgA Nephropathy is assessing "prognosis" based on data available at the time of biopsy

@goKDIGO suggest using the "prediction tool" that was derived from the largest & most geographically diverse cohort to date

#ISNWCN 🇲🇾 #Nephpearls
Feb 23, 2022 • 4 tweets • 6 min read
First clinical-grade porcine 🐖 kidney xenotransplant using a human decedent model ca. 2022 from @amjtransplant #NephJC #Nephpearls

#VisualAbstract by @NamrataYParikh

👉🏼 pubmed.ncbi.nlm.nih.gov/35049121/ Image Attitudes to Clinical Pig Kidney Xenotransplantation among Medical Providers and Patients ca. 2020 from @ASNKidney360 #Nephpearls

kidney360.asnjournals.org/content/1/7/657 ImageImage
Jan 30, 2022 • 4 tweets • 5 min read
Nephrolithiasis 101: When to order a 24-hour urine collection #Nephpearls

Multiple or metabolically active stones (stones that increase in size/ number w/in a year)

Children

Demographic groups not typically prone to stone formation

Stones other than those containing calcium ImageImage Interpretation of urine chemistries to identify lithogenic risk factors and assess the contribution of diet to the formation of kidney stones ca. 2016 from @ravineja #Nephpearls

sciencedirect.com/science/articl… Image
Jan 26, 2022 • 5 tweets • 9 min read
PREDNOS 2: Evaluation of Daily Low-Dose Prednisolone During URTI to Prevent Relapse in Children w/ Relapsing Steroid-Sensitive Nephrotic Syndrome ca, 2022 from @JAMAPediatrics #NephJC #IPNAJC #Nephpearls

#VisualAbstract by @drM_sudha

jamanetwork.com/journals/jamap… Low-dose versus conventional-dose prednisolone for nephrotic syndrome relapses: a randomized controlled non-inferiority trial ca. 2022 from @Ped_Neph #NephJC #IPNAJC #Nephpearls

#VisualAbstract by @md_abdulqader83

link.springer.com/article/10.100…
Nov 17, 2021 • 4 tweets • 6 min read
Clinical Practice Guideline for the Management of Glomerular Diseases ca. 2021 from @goKDIGO #NephJC #Nephpearls
#VisualGraphics by @michaelturk6

Executive Summary pubmed.ncbi.nlm.nih.gov/34556300/
Full Guideline pubmed.ncbi.nlm.nih.gov/34556256/ The spectrum of glomerular diseases from @neilturn #NephJC #Nephpearls

👉 global.oup.com/academic/produ…
Nov 5, 2021 • 4 tweets • 5 min read
Mineralocorticoid receptor (MR) has a role in:
👉 BP regulation
👉 Electrolyte Homeostasis

Overactivation of MR leads to:
👉 Inflammation and Fibrosis
👉 Sodium retention

#KidneyWk #Nephpearls #Cardiorenal ImageImage Finerenone: potent and selective non-steroidal MR antagonist (MRA) that is distinct from steroidal MRAs

#KidneyWk #Nephpearls #Cardiorenal ImageImage
Oct 13, 2021 • 5 tweets • 7 min read
New Creatinine- and Cystatin C–Based Equations to Estimate GFR without Race ca. 2021 from @NEJM #NephJC #Nephpearls
#VisualAbstract by @MdYoshinosuke

nejm.org/doi/full/10.10… ImageImage A Unifying Approach for GFR Estimation: Recommendations of the @nkf @ASNKidney Task Force on Reassessing the Inclusion of Race in Diagnosing Kidney Disease ca. 2021 from @JASN_News #NephJC #Nephpearls

jasn.asnjournals.org/content/early/… ImageImage
Sep 12, 2021 • 6 tweets • 6 min read
On the road again

Chapter 5: Functions of the Distal Nephron #Nephpearls

🎙 rosebook.club Gitelman syndrome: diagnostic criteria #Nephpearls
👉🏼 pubmed.ncbi.nlm.nih.gov/28003083/
Jun 23, 2021 • 6 tweets • 8 min read
Efficacy and safety of voclosporin versus placebo for #lupus nephritis (AURORA 1): a double-blind, randomised, multicentre, placebo-controlled, phase 3 trial from @TheLancet @BradRovin #NephJC #Nephpearls
#VisualAbstract by @katierizzolo
👉🏼 thelancet.com/journals/lance… Voclosporin: Hope on the Horizon for #Lupus Nephritis ⁉️ from @KidneyNews February 2021 issue #Nephpearls #NephJC
👉 asn-online.org/publications/k…
Jun 17, 2021 • 5 tweets • 5 min read
Happening now‼️
@NKFIllinois Controversies in #Nephrology #Nephpearls Image Balanced crystalloids vs saline in critically ill & non-critically ill adult patients from @NEJM #Nephpearls
#VisualAbstract by @aakashshingada
👉🏼 SALT-ED pubmed.ncbi.nlm.nih.gov/29485926/
👉🏼 SMART pubmed.ncbi.nlm.nih.gov/29485925/ ImageImageImage
Jun 7, 2021 • 11 tweets • 9 min read
Tweetorial: @goKDIGO Level 2B Recommendation - We suggest that adults w/ high BP & CKD be treated with a target SBP <120, when tolerated, using standardized office BP measurement (1/9) #Nephpearls
👉 kdigo.org/guidelines/blo… There is evidence that targeting SBP <120 when measured under standardized conditions, reduces CV events & all-cause mortality in CKD

📌 In most people w/ high BP (incl. frail & elderly), these benefits appear to outweigh the risks of harm (hypotension & AKI) (2/9) #Nephpearls
Apr 9, 2021 • 6 tweets • 6 min read
MOE: Phosphorus or Phosphate
👉 PROXIMAL Tubule: Main site for regulation of phosphate (some is reabsorbed with Na and H20; most is regulated by change in FGF23)
👉 DISTAL Tubule: Main site for regulation of calcium and potassium
#NKFClinicals #Nephpearls #CKDMBD ImageImageImage Phosphorus bioavailability "varies" by source
#NKFClinicals #Nephpearls Image
Mar 12, 2021 • 5 tweets • 7 min read
Acute on Chronic Liver Failure ca. 2020 from @NEJM #Hepatorenal #Nephpearls

nejm.org/doi/full/10.10… #Hepatorenal syndrome ca. 2019 from @CJASN #Nephpearls

👉 cjasn.asnjournals.org/content/14/5/7…
Mar 11, 2021 • 7 tweets • 8 min read
.@goKDIGO Controversies Conference on Home 🏡 Dialysis
#KDIGOHomeDialysis 🎧

👉🏼 kdigo.org/conferences/hd/ ImageImageImageImage Unmet need in kidney failure treatment worldwide
#KDIGOHomeDialysis 🎧
#WorldKidneyDay
👉🏼 thelancet.com/journals/lance… ImageImage
Mar 10, 2021 • 4 tweets • 7 min read
KALM-1: A Phase 3 Trial of Difelikefalin in Hemodialysis Patients with Pruritus ca. 2020 from @NEJM @sfishbane #Nephpearls
#VisualAbstract by @kidney_boy

nejm.org/doi/full/10.10… International Comparisons of Prevalence, Awareness, and Treatment of Pruritus in People on Hemodialysis ca. 2017 from @CJASN @DOPPStudy @WMRenalN @DrMattGB @brurobinson1 #Nephpearls
👉 cjasn.asnjournals.org/content/12/12/…
Sep 19, 2020 • 6 tweets • 4 min read
Who uses video conferencing? #HealthXPH 🇵🇭
👉🏼 addinfographic.com/video-conferen… The rise of video conferencing #HealthXPH🇵🇭
👉🏼 google.com/amp/s/technica…
Sep 16, 2020 • 10 tweets • 17 min read
Peritoneal Dialysis (PD) for AKI Treatment in the US: Brought to You by the #COVID19 Pandemic ca. 2020 from @ASNKidney360 @PD_Perls #CoronaKidney #Nephpearls
kidney360.asnjournals.org/content/kidney… ImageImageImageImage Increasing Peritoneal Dialysis (PD) Use in Response to the #COVID19 Pandemic: Will It Go Viral? ca. 2020 from
@JASN_News @PD_Perls @EdwinaB23513542 #CoronaKidney #Nephpearls
jasn.asnjournals.org/content/jnephr… ImageImage
Sep 4, 2020 • 17 tweets • 10 min read
Acute Hyperkalemia Webinar from @ISNkidneycare @goKDIGO #Nephpearls Classification of acute hyperkalemia #Nephpearls
Sep 2, 2020 • 15 tweets • 26 min read
Check out the latest issue of @ackdonline edited by @DrAnil001 and @bharvioza
"Dialysis Access: What is on the Horizon?"
#VascularAccessPearls #Nephpearls
sciencedirect.com/journal/advanc… ImageImage KDOQI 2019 Vascular Access Guidelines: What Is New? from @ackdonline @charmaine_lok @LouiseMoist1
#VascularAccessPearls #Nephpearls
ackdjournal.org/article/S1548-… ImageImageImageImage
Aug 23, 2020 • 7 tweets • 11 min read
Role of chloride in AKI from @ThepHunClub @scoca1 #Nephpearls
👉🏼 journals.physiology.org/doi/pdf/10.115… ImageImage In CKD patients, higher serum chloride was associated with a modestly steeper rate of eGFR decline, and may be a useful biomarker to predict CKD progression (ca. 2020) #Nephpearls
👉🏼 bmcnephrol.biomedcentral.com/track/pdf/10.1… ImageImageImage