PEXIVAS: In severe ANCA vasculitis, PLEX did not reduce the incidence of death/ ESKD
📌 A ⬇️ dose regimen of glucocorticoids was noninferior to a standard-dose regimen w/ respect to death/ ESKD
#VisualAbstract by @NephroGuy
#NephJC #Nephpearls
👉🏼 nejm.org/doi/pdf/10.105…
Therapeutic Apheresis 101
📌 Extracorporeal procedures whereby blood separation technology is used to remove abnormal blood cells and/or plasma constituents
🔲 Plasmamapheresis
🔲 Leukapheresis
🔲 Erythrocytapheresis
🔲 Thrombocytapheresis
#Nephpearls #NephJC
In plasmapheresis, or therapeutic plasma exchange (TPE), large quantities of plasma are removed from a patient and replaced with
👉🏼 Fresh frozen plasma (FFP), or
👉🏼 Albumin solutions in normal saline
#Nephpearls #NephJC
Indications for Urgent Plasmapheresis and Cytapheresis
#Nephpearls #NephJC
Complications of Plasmapheresis #Nephpearls #NephJC
Strategies to avoid complications during Plasmapheresis
#Nephpearls #NephJC
Randomized Trial of Plasma Exchange or High-Dosage Methylprednisolone as Adjunctive Therapy for Severe Renal Vasculitis (MEPEX) ca. 2007 from @JASN_News
#VisualAbstract by @madmagicdoc
#Nephpearls #NephJC
👉🏼 jasn.asnjournals.org/content/jnephr…
The role of plasma exchange in treating post-transplant FSGS ca. 2016 from @BioMedCentral
#Nephpearls #NephJC
👉🏼 ncbi.nlm.nih.gov/pmc/articles/P…
Principles of Separation: Indications and Therapeutic Targets for Plasma Exchange ca. 2014 from @CJASN
#Nephpearls #NephJC
👉🏼 cjasn.asnjournals.org/content/clinja…
MT @HerrmannMd SPECKS: Updates in ANCA Vasculitis
🔬 ANCA-type matters
💉 Less (no) cyclophosphamide
🩸 No Plasma Exchange‼️
💊 Less (no) glucocorticoids
#MayoUpdate2020 #Nephpearls
Key Findings in PEXIVAS ca. 2020 from @NatRevNeph #Nephpearls
nature.com/articles/s4158…
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