Breast biopsy for calcs. What is your diagnosis? Would you do stains? Since I’m asking that means I did 😉🔬 #breastpath @BIDMCpath @CollinsLauraC @jennpincus @RanaAldreesMD @tlabiano @lara_pijuan @ADamronMD @ariella8 @kis_lorand @TheISBP
Thanks for all the comments! Here are the stain. All (including p120, not pictured) were consistent with a lobular phenotype.
There were some hints in the background with areas of classical LCIS.
This is a nice example of florid LCIS with comedo necrosis and associated calcifications. The nuclei aren't pleomorphic enough for me to call PLCIS; I would classify these are type B cells. Exc was recommended and showed more florid and classical LCIS with no invasive component.
We have limited info on the natural history of PLCIS and FLCIS. Per the who 25-60% of cases on core are upgraded to carcinoma on exc therefore exc is recommended.
Here is an example of PLCIS with associated invasive lobular I had a couple years ago.
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