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Priya Rao, MD Profile picture
Priya Rao, MD
@priyaraomd
Mom, physician, urologic pathologist & Professor of Pathology @MDAndersonNews. ⚾️ and 🏊🏻‍♀️mom. Opinions my own. #PathTwitter

Apr 30, 2020, 5 tweets

I had a colleague from private practice ask me if I ever make a diagnosis of RCC with leiomyomatous stroma (RCCLMS). I thought this would be a good time to share an example. Continued 👇

An excellent summary of the molecular findings was published this mth in AJSP by @rajalbshah & @Kiril_T_Can suggests that these are unique tumors that harbor mutations in the TSC, MTOR and ELOC (TCEB) genes and are distinct CCRCC. Diffuse expression of CK7 is key.

These are sporadic counterparts of similar tumors seen in the setting of TSC. I have seen several cases like this and there was not a consensus on what these should be classified as. I like this terminology and will be using this in my practice. cc: @SurenaMatinMD

Reference:
"Renal Cell Carcinoma With Leiomyomatous Stroma" Harbor Somatic Mutations of TSC1, TSC2, MTOR, and/or ELOC (TCEB1): Clinicopathologic and Molecular... - PubMed - NCBI ncbi.nlm.nih.gov/pubmed/31850909

#GUpath.

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