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Stephen V Liu, MD Profile picture
Stephen V Liu, MD
@StephenVLiu
Director of Thoracic Oncology & Developmental Therapeutics @Georgetown @LombardiCancer; Host @IASLC Podcast; Chair #DCLung24 #TexasLung24 #HereWeGo

Jun 22, 2020, 5 tweets

#AACR20 Outcomes in KEYNOTE-189 (1L carbo + pem + pembro in #NSCLC) by STK11 and KEAP1 status presented by Shirish Gadgeel. Analysis on a (sizable) subset of the ITT showed STK11mt/KEAP1wt 8.7%, STK11wt/KEAP1mt 13.5%, double STK11/KEAP1 mt 10%. #LCSM #OncoAlert

#AACR20 STK11 and KEAP1 mutations associated with lower PDL1 expression and higher #TMB. #LCSM #OncoAlert

#AACR20 Addition of pembro to chemo improved RR independent of STK11 and KEAP1 mutation status. #LCSM #OncoAlert

#AACR20 Addition of pembro to chemo improved PFS independent of STK11 and KEAP1 mutation status. Though outcomes seem notably better in the wild type population. Addition of pembro improved outcomes but degree of improvement larger in wild type - #LCSM #OncoAlert

#AACR20 Survival benefit seen with addition of pembro to chemo independent of STK11 and KEAP1 mutation status. Again, outcomes better in wild type and HR more impressive (OS HR 0.75 in STK11 mt vs 0.59 in STK11 wt) but benefit seen across the board. #LCSM #OncoAlert

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