Hyman & Nestler, 1996 Initiation & adaptation: a paradigm for understanding psychotropic drug action pubmed.ncbi.nlm.nih.gov/8561194/
"...describes a paradigm...to conceptualize the drug-induced neural plasticity that underlies the long-term actions of psychotropic drugs in the brain."
Hyman & Nestler, 1996 Initiation & adaptation: a paradigm for understanding psychotropic drug action pubmed.ncbi.nlm.nih.gov/8561194/
"Chronic perturbations can produce different types of adaptations in the brain. Many adaptations can be viewed as compensatory homeostatic responses...."
Hyman & Nestler, 1996 Initiation & adaptation: a paradigm for understanding psychotropic drug action pubmed.ncbi.nlm.nih.gov/8561194/
"Rather than conceptualizing receptor down-regulation as the mechanism of action of #antidepressant drugs,
...conceptualize...as a marker of adaptation."
Hyman & Nestler, 1996 Initiation & adaptation: a paradigm for understanding psychotropic drug action pubmed.ncbi.nlm.nih.gov/8561194/
"However, it is less clear how compensatory adaptations to a drug would result in a therapeutic response."
Hyman & Nestler, 1996 pubmed.ncbi.nlm.nih.gov/8561194/
"#antidepressants do not produce addictive behavior, presumably because they do not cause adaptations within brain reward pathways or, if they do, they are unlike the adaptations produced by cocaine or opiates."
Hyman & Nestler, 1996 pubmed.ncbi.nlm.nih.gov/8561194/
"Chronic administration of psychotropic drugs creates
perturbations in neurotransmitter function...In the case of #antidepressant & antipsychotic drugs...adaptations
are therapeutic; in...drugs of abuse, the result is addiction."
Hyman & Nestler, 1996 pubmed.ncbi.nlm.nih.gov/8561194/
"Compared with drugs of abuse, much less is known
about the mechanisms by which chronic administration
of antidepressants, antipsychotic drugs, & lithium al-
ters brain function....similar types of mechanisms are involved."
Hyman & Nestler, 1996 Initiation & adaptation: a paradigm for...psychotropic drug action pubmed.ncbi.nlm.nih.gov/8561194/
"Specific syndromes of dependence & withdrawal depend [on] which particular brain pathways undergo long-term adaptations in response to repeated exposure to a drug."
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