Discover and read the best of Twitter Threads about #antidepressant

Most recents (9)

I'm in a particularly bad mood about the delusions of #psychiatry having spent the last week analyzing the case histories of 70 people with #antidepressant post-acute withdrawal syndrome #PAWS: duration 5-166 months, median 29.5 months. Lots of #psychiatrists involved. /1
5/70 reported recovered, 2 reported suicides. One suicide, better after 69 months of #PAWS, had an adverse reaction to an antibiotic that threw her back into the depths of withdrawal. The other, a 21-year-old woman, because of 38 months of post-SSRI sexual dysfunction #PSSD. /2
The 63 for whom I do not have reports of recovery from antidepressant post-acute withdrawal syndrome #PAWS or suicide have mostly been lost to follow-up. After years of reporting grueling symptoms, they didn't come back to tell us how they were doing. I hope they did recover.
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@dianamswancutt @shayla__love Truly excellent article, Shayla.

I know you couldn't cover everything -- @angpeacock1111 represents the epidemic of misdiagnosis & overprescribing affecting millions of people. Issues around psychosis are fascinating to academics, but there's a larger public health issue..../1
@dianamswancutt @shayla__love @angpeacock1111 Please consider another in-depth article on the patient movement represented in Medicating Normal. It is huge. There is a large peer support underground helping people deprescribe themselves -- they can't find doctors who know how to taper. Millions are looking for this help. /2
@dianamswancutt @shayla__love @angpeacock1111 Millions have been misdiagnosed & overprescribed. GPs mostly do this, but #psychiatry ignores it.

This is a patient movement that is not academic anti- or critical psychiatry, but very angry with #psychiatry for not stepping up for patient safety in #psychiatric treatment. /3
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"I sit here now in disbelief that I suffered from increasing anxiety for 9 years on Celexa (& 5 years on Zoloft), & the doctors simply raised the dose, not by a little, but by 50% each time....I developed dystonia in my feet & toes & my chest & neck...." survivingantidepressants.org/topic/16629-ro…
10 years of citalopram: "I had no idea what [dystonia] was, & doctors' appointments resulted in no doctor suggesting the [#antidepressant] could be the culprit. I didn't even know the terms dyskinesia or dystonia. No one mentioned them either." survivingantidepressants.org/topic/16629-ro…
"In 2011 I gave birth to a girl....the OB...switched me from Celexa 150 mg to Zoloft 10 mg with no cross taper, no advice, & no warning of the Hell I was about to endure. After many nights with no sleep due to this switch I finally started to sleep again." survivingantidepressants.org/topic/16629-ro…
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@DBDouble @f_hieronymus @awaisaftab @rcpsych I took it as "contend" but @f_hieronymus does not seem to be aware that while #antidepressant withdrawal problems are well-documented, this awareness has not translated to clinical practice for 60 years. What is the nature of the barrier? This is the epistemiological question.
@DBDouble @f_hieronymus @awaisaftab @rcpsych First, late '80s-early '90s, new #antidepressants were held not to have a withdrawal syndrome (despite known pharmacological principles of psychotropics & appearance in clinical trials).

Then, starting with Schatzberg et al., 1997, withdrawal syndrome was held to be trivial /1
@DBDouble @f_hieronymus @awaisaftab @rcpsych Schatzberg et al., 1997 claimed #antidepressants "discontinuation" symptoms were mild, transitory, lasting only a few weeks, barely needing tapering. This held sway to the present day (despite decades of many, many patient complaints of more severe problems). /2
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Hyman & Nestler, 1996 Initiation & adaptation: a paradigm for understanding psychotropic drug action pubmed.ncbi.nlm.nih.gov/8561194/

"...describes a paradigm...to conceptualize the drug-induced neural plasticity that underlies the long-term actions of psychotropic drugs in the brain."
Hyman & Nestler, 1996 Initiation & adaptation: a paradigm for understanding psychotropic drug action pubmed.ncbi.nlm.nih.gov/8561194/

"Chronic perturbations can produce different types of adaptations in the brain. Many adaptations can be viewed as compensatory homeostatic responses...."
Hyman & Nestler, 1996 Initiation & adaptation: a paradigm for understanding psychotropic drug action pubmed.ncbi.nlm.nih.gov/8561194/

"Rather than conceptualizing receptor down-regulation as the mechanism of action of #antidepressant drugs,
...conceptualize...as a marker of adaptation."
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Why #psychiatry research seems to exist in a parallel universe: "Academic psychiatrists who pursue research careers may not have patients after residency, let alone practice psychotherapy." -- psychologist Jonathan Shedler psychiatrictimes.com/view/psychoana…
"But aren’t we seeing the same kind of arrogance & reductionism in #psychiatry today?....I cannot tell you how many depressed patients I’ve worked with...successfully....who had been on 1 medication after another for years or decades with little benefit." psychiatrictimes.com/view/psychoana…
"These patients often go from #antidepressants to mood stabilizers to atypicals....We see polypharmacy nightmares, with patients on 5 or 6 or more #psychiatric medications, and they are just as depressed as when they started." psychiatrictimes.com/view/psychoana…
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"I was eventually convinced by a psychologist (and my wife) to try Zoloft because I was one of those people that was either born with a chemical imbalance or I acquired one due to my childhood traumas. Well...those 3 days were...pure hell on earth." survivingantidepressants.org/topic/16251-ps…
After 2 years on #antidepressants: Diagnosed Paroxysmal Supra Ventricular Tachycardia "24 years of my life chasing this, never not once did any medical or other professional suggest I go see a cardiologist but they were all too willing to take my money.." survivingantidepressants.org/topic/16251-ps…
"I was very very ill about a week after I started Pristiq & I told my GP numerous times but she just said to "keep going" as it takes about 6-8 weeks to kick in and start working...it was obvious she was in too far over her head..." survivingantidepressants.org/topic/16251-ps…
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At age 33: "I ran into a situation that required me to confront someone. As that time approached, I became increasingly anxious about my ability to handle the situation....I went to my doctor for help. He immediately threw 20 mg of Prozac at me...." survivingantidepressants.org/topic/22572-by…
"I left my GP & sought out the top Psychiatrist in my city...By this time, I was such a mess due to the effects of the Prozac, I was diagnosed with GAD Generalized Anxiety Disorder....We tried several other types of antidepressants...." survivingantidepressants.org/topic/22572-by…
"we tried several other types of antidepressants over the following months....Each one effecting me the same way....Over the last 20 years I ran into a few occasions that required the medication to be increased....Again, I would lose my mind!" survivingantidepressants.org/topic/22572-by…
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1/ Thread: New study forthcoming on whether #gene-testing can help guide #antidepressant selection for #depressed patients who have failed to respond to 1 or (on average) 3-4 trials of medication. bit.ly/2LQU75I I have been skeptical: mostly, scant added value…
2/ & I found the reporting of this study annoying. On the primary endpoint, improvement in average #depression rating scores, the gene-testing failed. Patients whose MDs chose new meds w/o help of gene tests did just as well—& yet news reports suggested that tests can help…
3/ That's because the gene testing led to a choice of new meds that led to significantly more remissions (patient no longer depressed) and responses (halving of symptom burden). In general, in drug trials, response/remission shows antidepressants to better effect…
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