Jon Deeks FMedSci Profile picture
Biostatistician trying to work out the best ways of evaluating medical tests. Views expressed are my own and do not necessarily reflect my employer or funders.

Aug 26, 2020, 6 tweets

We have published our next Cochrane review of Covid-19 tests:

Rapid, point‐of‐care antigen and molecular‐based tests for diagnosis of SARS‐CoV‐2 infection - Dinnes, J - 2020 | Cochrane Library cochranelibrary.com/cdsr/doi/10.10…

Includes pre-prints and published studies available up to the end of May. We found 18 study cohorts with 3198 unique samples, of which 1775 had confirmed SARS‐CoV‐2 infection.

Due to the importance of these tests we currently updating to end of July and will republish in weeks.

Most of the data included here are from remnant sample studies, didn't use the tests according to their instructions, and were shockingly poor in other ways.

Hoping for better evidence in the update

Studies of antigen tests broke records for heterogeneity in sensitivity !

Moleular tests showed some difference between brands, but remember how poor these studies are

We urgently need more studies to be able to provide helpful evidence

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