1) Migraine Premonitory(Prodromal) Phase::
Presences of non-painful Symptoms, which can start hours to days before the onset of migraine pain and can be predictive of an impending headache.
2) Three Separate Groups of Symptoms::
1::Fatigue & Cognitive changes...
Concentration difficulty, Irritability, depression, fatigue, memory impairment.
2::Homeostatic Changes...
Food craving, Thirst, Yawning, Increased Urination, Sleep disturbance.
3) 3::Sensory Changes...
Photo, phono, osmo, Phobia, nause, neckstiffness.
4) Regions Involved::
Hypothalamus, Ant-cingulate, Amygdala, L-ceoruleus, Brainstem,Occipital Cortex.
5) Hormones/Chemical Involved::
Neuropeptide-Y, Orexin, Somatostatin, Cholecystokinin, Dopamine, ADH, Melatonin.
THERAPEUTIC Importance::
Dopamine +Triptans
Orexin
Somatostatin
Melatonin
(Melatonin and Somatostatin already showed its efficacy in Cluster Headache)
6) #Neurology #neurologyresident #neurologist #MedTwitter #NeuroTwitter #vascularNeurology #headache #migraine #stroke #triptans #melatonin
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