Out of my 91 papers on rapamycin, I select five for a brief introduction and historic perspective
1.Most recent and comprehensive analysis why rapamycin can and should be used to treat aging and prevent diseases
ncbi.nlm.nih.gov/pmc/articles/P…
2. By 2010, 12 predictions of mTOR theory of aging have been confirmed (including life extension in mice). “The only prediction remained in 2010 to be confirmed: rapamycin will become the cornerstone of anti-aging therapy in our life time”
pubmed.ncbi.nlm.nih.gov/20436272/
3.In 2010, Intermittent (6 days per 4 weeks) administration of Rapamycin slows aging and extends maximal lifespan in mice
ajp.amjpathol.org/article/S0002-…
4. In 2008. mTOR drives cellular senescence and rapamycin suppresses senescence
pubmed.ncbi.nlm.nih.gov/19471117/
5.Original hyperfunction theory of mTOR-driven programmed-like aging and rapamycin applications to treat all age-related diseases by suppressing aging
pubmed.ncbi.nlm.nih.gov/17012837/
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