Mikhail Blagosklonny Profile picture
MD/PhD. Professor of Oncology In Search of Immortality. Longevity, Aging #Rapamycin #mTOR, low carb/keto diet, weight loss. Editor https://t.co/vOLFBqirGU
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Sep 24, 2021 5 tweets 1 min read
1/5
In 2014, I published "Koschei the immortal and anti-aging drugs" presenting anti-aging combo/recipe. Dr Alan Green named it Koschei formula and implemented in the clinic (by now he develops his own formula)
pubmed.ncbi.nlm.nih.gov/25476900/#&gid… 2/5
Since that time, I have significantly updated the formula. One of notable change is Low Carb instead of Low Fat diet. Importantly, now there are many Koschei formulas depending on a particular person. It is addressed to MDs not patients.
Sep 24, 2020 5 tweets 2 min read
Out of my 91 papers on rapamycin, I select five for a brief introduction and historic perspective

1.Most recent and comprehensive analysis why rapamycin can and should be used to treat aging and prevent diseases

ncbi.nlm.nih.gov/pmc/articles/P… 2. By 2010, 12 predictions of mTOR theory of aging have been confirmed (including life extension in mice). “The only prediction remained in 2010 to be confirmed: rapamycin will become the cornerstone of anti-aging therapy in our life time”

pubmed.ncbi.nlm.nih.gov/20436272/
Sep 1, 2020 4 tweets 1 min read
1/3Some senolytics (drugs that kill senescent cells selectively) may work because they are not senolytics, instead inhibiting kinases, including mTOR, acting as gero-suppressants 2/3Pure senolytics, a form of chemotherapy, are not selective enough for senescent cells, killing non-senescent cells too. Second, in some cases, killing senescent cells can further impair organ function. Imagine killing senescent neurons, beta-cells, retinal cells.
Jun 25, 2020 4 tweets 1 min read
@nntaleb
1/3 Every day we play Russian Roulette. Our decisions are NOT based on the probability of death. Instead, we do what other people do and especially ! what we already done successfully. 2/3 COVID-19 death probability for young girls >> old men (perhaps 1000 fold). But I observed that more old men than young girls are not wearing masks in the park.
Jun 5, 2020 8 tweets 1 min read
“Fast food” is food that is prepared quickly and is eaten quickly or taken out.
I do not see anything bad in fast food, except that it contains a lot of carbs. Without carbs (bread, fries etc) it would be called ketogenic diet (almost) The focus should be shifted from whether food is "fast" or "slow" to carb content. Zero carb fast food seems fine to me. Fast meat without bread for example
Mar 10, 2020 4 tweets 2 min read
1/3 #Aging is the main problem during #coronavirus epidemic. Coronavirus is not lethal before aging (< 18 yo) and mortality increases exponentially with age, like mortality from aging itself. We may say that people still die from aging which allows the virus to become lethal 2/3 If infected, a person has ~ 3 times more chances to die compared with usual age-related mortality during one year For example (numbers are approximate), a 60 yo woman already has 1% chances to die before 61 birthday and ~3 % from the virus.
Mar 8, 2020 4 tweets 1 min read
Aging CAN exist because it is shadowed from natural selection. Multiple causes may cause different kinds of aging that would occur at different speed. Faster (because natural selection promotes it) is aging caused by something that is essential early in life but harmful later e.g. mTOR driven growth program (quasi-program of aging). “The brightest flame casts the darkest shadow” Slower, accumulation of molecular damage, because its harmful from day 1 (never useful), so natural selection does not promote it and even works against it
Mar 3, 2020 4 tweets 1 min read
Increase of functions that drive age-related diseases eventually leads to loss of functions. For example, increase in blood pressure with age (from childhood) may eventually lead to heart failure and drop in blood pressure.
Figure 1 explains
tandfonline.com/action/journal… Cellular hyper-functions (tissue specific,mTOR dependent cellular senescence) lead to systemic hyper-functions (hypertension, hyperinsulinemia, hyperlipidemia, hyperglycemia , etc) and eventual overt diseases , see also fig 7
Feb 28, 2020 4 tweets 2 min read
I predict that so-called more selective mTORC1 inhibitors will have equal or inferior antiaging effects compared with #rapamycin. I predict that maximal anti-aging effect will be achieved with a combination of high doses of rapamycin plus low doses of pan-mTOR inhibitors such as Torin-1, which can inhibit rapamycin-insensitive functions of #mTORC1. But doses must be low to avoid inhibition of other kinases and side effects. Thus High rapamycin plus Low pan-mTOR inhibitor