There’s a curious correlation between countries/regions of high prior SARS2 exposure and a resurgence upon the start of mass V immunization programs. I’ve been thinking a lot about this lately, and the only explanation that could fit observations is… 1/
bmj.com/content/372/bm…
reactivation of dormant viruses in the population. (Seasonal) respiratory viral dormancy has been debated a lot for decades, but there’s still no consensus on where exactly these virions could lay dormant in the body, nor on the trigger(s) & mechanism(s) responsible for… 2/
reactivation. In light of recent research, my (educated?) guess is that the small intestine, and associated immune structures, is more likely place for this to occur than the respiratory tract. Admittedly, this is speculative, but neither implausible nor could I come up with… 3/
an explanation that better fits what’s seen in more and more countries.
Initially, I thought that poorly organized vaccination campaigns and careless behavior of vaccinated might explain the phenomenon, but it’s been becoming clear that this cannot be the case.
➟ #dormancy❓4/4
I’ll keep amending this mini-thread with (potentially) supporting evidence.
Just as infection with other viruses, vaccination can also reactivate e.g. shingles. gizmodo.com/what-to-know-a…
Immunosuppressive states are also known to result in reactivation of dormant viruses. Space travel is one such example. The week (or so) following a strongly immunogenic systemic vaccination is also immunosuppressive.
popsci.com/spaceflight-re…
Adding this case report here. Thanks for sharing.
Evidence for viral dormancy at least up to 6 months.
I forgot about one of the most obvious examples of (transient) immunosuppression: irradiation. Note the time span of 1-2 weeks.
academic.oup.com/jes/article/5/…
These findings may support the case.
Longitudinal following a lot of cats showed that feline coronavirus can establish chronic infection and perhaps dormancy with periodic deactivation as well. (No sequencing was done to confirm.)
bvajournals.onlinelibrary.wiley.com/doi/full/10.11…
Look at this, population data from Denmark.
“Suspected COVID-19 cases that occurred within 7 days after any vaccination were 409 in the vaccine group vs. 287 in the placebo group.”
Largest collection of real world examples I’ve seen so far.
The phenomenon described in Ebola as well.
Now, this is really intriguing.
The discrepancy in below data from Israel suggests the same. Cases and deaths increase during the ~2-week period following the first vaccination. I find it a bit weird that the authors decided not to report on this part at all.
Here you go. Both antigen (S1) and viral RNA is confirmed >12 months in monocytes derived from survivors of severe COVID and ‘long COVID’. Hopefully the authors will map other antigen presenting cells and various tissue localization in the future.
biorxiv.org/content/10.110…
Similarly intriguing development in Uruguay.
“Almost half of Kenyan adult donors had evidence of past SARS-CoV-2 infection by March 2021.
***Between March and June, 2% of the population were vaccinated against COVID-19 and the country experienced a third epidemic wave***.”
Emphasis mine
medrxiv.org/content/10.110…
Look how this has been going.
nejm.org/doi/full/10.10…
Long COVID is correlated with EBV reactivation. Some people describe ‘long vaccine’ as well. Intriguing
mdpi.com/2076-0817/10/6…
The increased odds can easily be observed in these data, but there's an uptick even after the second jab. This phenomenon is clearly related to vaccination.
Intestinal biopsy study/abstract
“More than half a million doses are being administered a day”
+ “We’re currently experiencing the highest number of new cases reported so far”
Where have we seen that combo before? 🤔
nature.com/articles/d4158…
Proper observation: “During the first few days after vaccination… the odds of vaccinated people testing positive was higher” 😮
Dubious explanation:
“suggesting that vaccination was being targeted at those at higher risk of infection.” 🤡
is.gd/UfSuAX
A pair of tweets, more food for thought along the above.
It seems that the effect is negatively correlated with age, so the highest risk of immunosuppression is in kids!
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