Here I was called a COVID denier (what is that?), even though almost everything I stood for has been very close to reality since about March 2020. In fact, the only thing I was wrong about was the real world CFR of the virus. Back then I didn’t understand that poor management…

https://twitter.com/angie_rasmussen/status/1329060020495892480

…was responsible for many deaths. Too early and unnecessary use of ventilators, too early and too high dose use of dexamethasone, remdesivir administration in hospitalized patients, avoidance of adding cheap and very low risk prophylactics, etc.
I only recognized these later.

Dude either has no clue about what ‘immunity’ is, or has a very narrow tunnel view of it. Alternatively he’s deliberately spreading misinformation here.

https://twitter.com/tuliodna/status/1493468728243236868

NB, more typical courses have been:
Infection with Wuhan + Omicron
Infection with Alpha + Omicron
Infection with Wuhan + Delta + Omicron
Etc.
Guess how these typical scenarios fair against vaccination + Omicron? Yep, you’re absolutely right.

If you’re heading to the hospital with COVID make sure to declare that you’re allergic to remdesivir. It’s ineffective anyway.

Kidney disorders as serious adverse drug reactions of remdesivir in coronavirus disease 2019: a retrospective case–noncase study kidney-international.org/article/S0085-… While remdesivir is still touted as ‘safe and effecrive’ in the COVID response of many countries, public health officials start removing health insurance reimbursement for vitamins and minerals due to lack of efficacy shown… Could you make this up? businessinsider.co.za/medical-scheme…

‘Pandemic’ (changed by WHO in 2009)
‘Vaccine’ (changed by CDC in 2021, where kefir or vitamin D now fully qualify)
‘Peer reviewed’ (clueless people repeat it as mantra)
‘Breakthrough infection’ (if there’s robust immunity
‘T cells’ (ignored and ridiculed until Omicron appeared)

https://twitter.com/madeofmistak3/status/1468631792315817986

Oops, some editing issue at ‘peer reviewed’
If there’s robust immunity infecfion doesn’t occur. It only does if immunization was unsuccessful.

A recently developed method, that expresses full spike trimers, enables more accurate measurement of binding IgG1 antibodies. Quite a few interesting results in this study.
First of all, the second dose of mRNA vaccines adds very little extra binding. medrxiv.org/content/10.110… More importantly, the absolute increase in Delta variant binding antibodies following administration of the 2nd dose to previously infected people is limited to a small subset of adults. At the same time, the relative number of Delta binding Ab to non-binding (old Wuhan) Ab is…

Let me strip the unnecessary narrative out of this otherwise nice study/abstract to get a clear picture. Short thread 🧵

Anti-SARS-CoV-2 receptor binding domain antibody evolution after mRNA vaccination
nature.com/articles/s4158… How infection elicits broad protection
“SARS-CoV-2 infection produces B cell responses that continue to evolve for at least one year. During that time, memory B cells express increasingly broad and potent antibodies that are resistant to mutations found in variants of concern”

Antibody depending enhancement was a threat that looked possible (or even likely) a year ago, based on experience with historical CoV vaccine attempts. Then it started to look like a non-issue during trials and early rollout. Now it’s back on the table. First described in… 1/7 …a paper published in February, i.e. prior the emergence of Delta and only looking at Wuhan-Wuhan re-exposure. Enhancement was seen in just a small subset of macaques:
cell.com/cell/fulltext/…
Then a study that used a Wuhan-Delta sequence of spike exposure found something… 2/7

In below thread immunosuppression was identified as the likely mechanism for the observed ⬆️ risk of COVID during the 1st 14 days post first jab.
A study looking at immunological changes in yellow fever vaccination reported very similar trajectories. tandfonline.com/doi/full/10.10…
1/4

https://twitter.com/gerdosi/status/1387413025926361093

“We found that the numbers of leukocytes sharply declined 7 days after vaccination, increasing back to baseline levels after 14 days. In contrast to primary vaccination, we did not observe a decrease of cell counts after recall vaccination (10 years after primary).” 2/4

Pan-coronavirus epitopes, e.g. the replication complex, which is the first to be expressed in host cells, do confer protective preexisting immunity. To the extent that people who harbor such tissue resident memory T cells don’t even produce antibodies.
medrxiv.org/content/10.110… Similar findings in a peer-reviewed study.
“CD8+ T cells with these conserved specificities are much more abundant in COVID-19 patients with mild disease versus those with a more severe illness, suggesting a protective role.”
med.stanford.edu/news/all-news/…
immunology.sciencemag.org/content/6/61/e…

Similarly intriguing development in Uruguay.

https://twitter.com/RuminatorDan/status/1409602844949467137

“Almost half of Kenyan adult donors had evidence of past SARS-CoV-2 infection by March 2021.
***Between March and June, 2% of the population were vaccinated against COVID-19 and the country experienced a third epidemic wave***.”
Emphasis mine
medrxiv.org/content/10.110…

Once again, old science (image to the left) predicts new findings (image to the right). One thing remains common: negligence

Accumulation of nanocarriers in the ovary: A neglected toxicity risk? sciencedirect.com/science/articl… Reviewed here:
Potential adverse effects of nanoparticles on the reproductive system
dovepress.com/potential-adve…

1/ I have a thread about natural immunity to SARS-CoV-2, but I was asked to do a comparison with vaccine induced immunization. Interestingly, deep analysis of the two is largely missing. A recent study will do the job,
science.sciencemag.org/content/early/…

https://twitter.com/gerdosi/status/1343565534512742402?s=20

2/ but we need to focus on results, not conclusions, because even though the study was designed to compare the two types of immunization, plus added the effect of a booster jab on top of infection, the interpretation is a bit twisted to mostly compare the 2 jab scenarios.

There’s a curious correlation between countries/regions of high prior SARS2 exposure and a resurgence upon the start of mass V immunization programs. I’ve been thinking a lot about this lately, and the only explanation that could fit observations is… 1/
bmj.com/content/372/bm… reactivation of dormant viruses in the population. (Seasonal) respiratory viral dormancy has been debated a lot for decades, but there’s still no consensus on where exactly these virions could lay dormant in the body, nor on the trigger(s) & mechanism(s) responsible for… 2/

Adding this post to the thread

https://twitter.com/FiorediNotte33/status/1386532787776196614

Neurological complications of COVID-19 are the result of spike mimicry induced autoimmunity?
“these mAbs target both anti-viral and anti-neural antigens—including one mAb that reacted to both spike protein and neural tissue.”
cell.com/cell-reports-m…

An excellent bird’s view of the same topic.
cell.com/cell-systems/f… “20 novel human peptides mimicked by SARS-CoV-2 have not been observed in any previous coronavirus strains (HCoV, SARS-CoV, and MERS).”
nature.com/articles/s4142…

What a coincidence
“The binding epitope on S harbors a sequence motif unique to SARS-CoV-2 (not present in other SARS-related coronaviruses), which is highly similar in both sequence and structure to the bacterial superantigen staphylococcal enterotoxin B”
pnas.org/content/117/41… Now, this story keeps unfolding.
“the trimeric spike protein of SARS-CoV-2 could bind to TLR4 directly and robustly activate downstream signaling in monocytes and neutrophils.” Via MyD88 and NFκB

https://twitter.com/biorxiv_immuno/status/1340118645624729600?s=21

Short thread.
If you’re not through COVID-19 yet I really hope that you’ve spent the last couple of months preparing for it. Losing beer belly, being out in the sun, and eating nutrient dense, fat soluble vitamin-rich foods. Definitely don’t rely only on vaccines if you’re… …(metabolically) obese. Why? By now, it’s clear that obese are not only susceptible to more severe COVID, but also to influenza.
➡︎ Overweight and obese adult humans have a defective cellular immune response to pandemic H1N1 Influenza A virus onlinelibrary.wiley.com/doi/full/10.10…

Nasal immunization could be the most efficient and potentially least harmful against coronaviruses, in line with the primary role of the mucosal barrier in providing protection. cell.com/immunity/fullt… “mortality in 12- to 22-month-old mice infected with SARS-CoV or IAV was reduced from 80 to 100% to 0 to 10% by treatment with a TLR3 agonist, poly(I·C), with concomitant increased expression of interferon (IFN) and other proinflammatory molecules”
jvi.asm.org/content/86/21/…

I keep hearing that SARS-CoV-2 is not like the flu, it’s a totally different virus. Well, can you spot the differences & similarities? I highlighted the most important commonality, i.e. how they typically kill.
mdpi.com/1999-4915/12/4…
sciencedirect.com/science/articl… cdc.gov/flu/symptoms/s…

There seems to be a lack of understanding how the respiratory immune system works, and why only severe cases of viral infections result in high serum IgG levels. The reason: successful containment of a virus in the upper respiratory tract involves IgA, not IgG.
@FatEmperor Study jimmunol.org/content/173/3/…

I’m starting a thread of interesting recent reviews that I skimmed and recommend to read. First one is about the paternal epigenetic programming of offspring metabolism.

Diet-Induced Modification of the Sperm Epigenome Programs Metabolism and Behavior cell.com/trends/endocri… “mitochondrial DNA (mtDNA), the only form of non-nuclear DNA in eukaryotic cells, is a major activator of inflammation when leaked out from stressed mitochondria”

Emerging Role of Mitochondrial DNA as a Major Driver of Inflammation and Disease Progression cell.com/trends/immunol…