My first Substack on Spike Escape and Directed evolution.
anandamide.substack.com/p/directed-evo…
Supporting References.
Delta variant viral load.
poseidon01.ssrn.com/delivery.php?I…
Pfizer lymphocytopenia.
nejm.org/doi/suppl/10.1…
After the 1st shot in the Pfizer trial.
Nearly 1.5 X (409/287) as many people in the Vax arm became C19+.
You don’t hear about that in the news.
Is this related to neutropenia/lymphocytopenia?
Check out the bottom graph.
Unvaxxed in the middle?
nejm.org/doi/full/10.10…
I have included more references to the thread that many people provided. Thank you. Fixed a few links and tried to clarify a few points people were confused over.
That was written at 1:00AM and I didn't find the Edit button until an hour ago:)
Someone forwarded me a lazy take down on Ivermectin (Not from a PCR expert).
S/He clearly read the Abstract of this small 24 person study which does mislead the average reader into thinking you can't obtain viral inhibition with human doses of IVM.
thelancet.com/action/showPdf…
And while the study didn't find significant differences in the patients that were called positive (they nearly all were), it did see a shift in Viral loads on IVM (orange). Thats a log scale on Y.
So, why does the article tone this observation down? The abstract and conclusion bury this? Read it and decide for yourself but be certain to read the COI section.
Let's look at another slightly larger study in the same Journal.
thelancet.com/journals/eclin…
In this case the authors have internal controls in their PCR.
And they understand p450 genetics enough to know that you shouldn't just measure the oral dose given, but instead measure the plasma level of the drug as some patients clear the drug quickly.
When these variables are controlled for you can see a reduction in viral load. This is a very important metric for the pandemic. If you want to dial down the scariant parade, you need to slow the polymerase or increase its fildelity. Vax programs that don't change viral load...
Invite more viral evolution.
But there is more. If you are a PCR geek that has any experience making reversible terminators you know that PCR signal is going to over estimate infectious viral load particularly when Ivermectin has many modes of action. So, one should confirm.
What is the impact of Ivermectin not just on qPCR signals of the viral RNA but on viability or culturability of the virus? Recall, Not all RNA is full length and when you stall polymerases, your qPCR signal and culture signal can diverge.
medrxiv.org/content/10.110…
I can imagine if you start this study with late treatment, it will be too late to see the difference as once the virus has gone exponential, the drug may not be able to stop it. Apply it early and you are far more likely to see the the polymerae stall.
This review from Trevor Bedford confirms this.
Spike evolution is off the charts.
He is obfuscating the truth by calling it “partial immunity”.
Just say it!
Spike only Vax w/ same CT is Dumb.
Good to see him visualize a world without lockdown.
This charts lay out the Ks/Ka evaluation mentioned above.
Share this Scrolly Tale with your friends.
A Scrolly Tale is a new way to read Twitter threads with a more visually immersive experience.
Discover more beautiful Scrolly Tales like this.