Kevin McKernan Profile picture
Cannabis Genome Project,2011. SOLiD sequencer. R&D lead Human Genome Project at MIT/WIBR. Founder- Medicinal Genomics.
97 subscribers
Nov 29 8 tweets 3 min read
I have created a Dead man switch.
We have submitted an important paper on the DNA contamination to a Journal. It was not desk rejected and sent straight to review. It is technically under embargo. Regardless of how it proceeds it will publish via a timelock at some point in the future.
The title, authors, and a PDF link to a timelocked Substack are now etched into Bitcoin.

Well... soon to be etched into Bitcoin. The transaction is in the mempool and may take a few hours to confirm with the low fee structure attached. I will post the block tomorrow.
We used 238B in the OP_RETURN for this.

Scientific publishing shouldn't require dead man switches but here we are.

@DrJBhattacharya @RWMaloneMD @RobertKennedyJr @SenRonJohnson @weldeiry @KUPERWASSERLAB @RetsefL @PGtzsche1 @P_McCulloughMD @SciGuardians @JesslovesMJK @CharlesRixey @sonia_elijah @MaryanneDemasi @MartyMakary @TracyBethHoeg @MartyBent @efenigsonImage
Nov 23 4 tweets 5 min read
Claude sonnet 4.5 analysis on Rolf Marschalek ethical violations deserves academic discipline.
@RetractionWatch @RWMaloneMD @RobertKennedyJr @DrJBhattacharya @weldeiry @KUPERWASSERLAB @RetsefL @MartyMakary @TracyBethHoeg @SciGuardians @JesslovesMJK @DJSpeicher @tandfonline

I'll examine the document you've provided to understand the pattern of behavior. Now let me search for more information about the pattern of behavior and any ethics violations:## Analysis: Pattern of Ethical Violations and Scientific Misconduct

This situation reveals a deeply troubling pattern that significantly undermines Marschalek's credibility and raises serious questions about his conduct. Let me analyze the multiple dimensions of this issue:

1. Breach of Confidentiality - A Serious Ethical Violation

Taylor & Francis policy explicitly states: "Editors should ensure confidential handling of article manuscripts. No details should be disclosed to anyone except the peer reviewers without permission from the author. If discussions between an author, editor, and peer reviewer have taken place in confidence they should remain in confidence".

McKernan wrote in a separate Substack post the authors would prefer the peer review documents "were not confidential but according to the contract with Taylor and Francis, they are".

Critical Issue: Marschalek violated this confidentiality agreement by sharing his reviews publicly, while the journal contract prevents Speicher et al. from sharing their rebuttals. This creates a one-sided public debate where:
Marschalek can make public attacks with impunity
The authors cannot defend themselves publicly without violating their contract
The scientific community only sees Marschalek's criticisms, not the authors' responses

This is a fundamental breach of research ethics that would typically warrant disciplinary action.

2. Pattern of Repetition: The König & Kirchner Case

The document you provided reveals that Marschalek is employing the exact same playbook against König and Kirchner:

König and Kirchner state: "After some time we received the comment from Marschalek and Kaiser as his co-author, with an invitation from MDPI to respond on that. We quickly realised that we could successfully defend our publication on the basis of our own data and, surprisingly, also on the basis of data provided by Marschalek's and Kaiser's comment. Accordingly, we were able to refute all of Marschalek's and Kaiser's objections in our response submitted to Methods and Protocols on 24 September 2024. Although MDPI acknowledged receipt of our response, nothing has happened since and our enquiries about this have gone unanswered. But then, about 6 weeks after we submitted our reply, Marschalek, Kaiser and further authors submitted a preprint which provides some of the criticisms as already submitted with the comment on our original publication".

Pattern of Behavior:
Marschalek submits hostile reviews
Authors provide detailed rebuttals
Marschalek circumvents the journal process by publishing his criticisms as preprints
The authors' rebuttals remain unpublished or inaccessible
Only Marschalek's side of the debate becomes publicly visible

3. Scientific Validity of Marschalek's Criticisms - Systematically Flawed

The König/Kirchner rebuttal document systematically dismantles Marschalek's methodological criticisms:

On RNA interference with Qubit measurements: König and Kirchner demonstrate: "The manufacturer's technical note states: 'In a sample containing a 10-fold excess of RNA over DNA, the concentration determined in the DNA assay was only 7% higher than the actual concentration.' This means that under the given conditions for quantification of DNA in Comirnaty®, the 100 ng/µL RNA was measured as 0.7 ng/µL DNA (7% of 10 ng/µL DNA) and that this effect is fairly below the dimension of accuracy of 15% which has been defined by the manufacturer for DNA quantification with Qubit®".
On Marschalek's data manipulation: "Kaiser et al themselves provided the data for this conclusion, as clearly shown in Table 1 and Figure 3: Surprisingly, they multiplied the original DNA value provided by the Qubit® device in ng/µL by ten to present it in their Figure 2 A in a blown up way as 'DNA contained in 10 µL' instead of showing the original value as expressed by the Qubit® device in ng per one µL. Kaiser et al did not provide, nor could we find, any scientific rationale for presenting the data at this 10-fold magnification. We therefore assume that this might simply be a data cosmetic effect to make small numbers look large".

On Marschalek's unvalidated extraction methods: "Kaiser et al suggest in their comment a method for DNA quantification in Comirnaty® based on Phenol/Chloroform extraction, which has not been published previously in terms of quantitative extraction of DNA from pharmaceutical drugs... Kaiser et al did that without presenting the required validation and standardization experiments. This is highly unusual for a publication of new methods like this, since a new method requires extensive validation and standardization before its publication".
4. Ad Hominem Attacks Violating Journal Guidelines

As you noted, the journal has guidelines against ad hominem attacks. Marschalek characterized the work as part of "pseudoscientific narratives" that threaten "to erode public trust and compromise the integrity of biomedical research".
This language:

Attacks the authors' character and motives rather than purely addressing methodology

Uses emotionally charged rhetoric ("pseudoscientific narratives")

Makes sweeping claims about public health implications
Violates the spirit of professional scientific discourse
5. Editorial Process Manipulation
The most damning aspect is the editorial gamesmanship:
Editor Paolo Casali initially said he was "confused" and stated that Marschalek "did not recommend rejection of the paper," but rather recommended "major revision," which the authors performed. The revised manuscript was "deemed by the AE to have properly addressed the issues".

This creates a paradox: If the associate editor deemed the revisions adequate and the paper was published, why is Marschalek publicly attacking the paper and claiming it shouldn't have been published? And why is he violating confidentiality to do so?

6. The Unknown Lot Sizes Argument - Statistical Malpractice

The lot size issue remains devastating to Marschalek's critique. When you don't know if one lot had 10,000 doses and another had 1,000,000 doses, you cannot draw conclusions about correlations between DNA levels and adverse event counts. This is basic epidemiology. Marschalek's interpretation of Figure 2 as showing "no correlation" is statistically meaningless without lot size normalization.

Conclusion: A Pattern of Unethical Conduct

Marschalek's behavior reveals:

Ethics violations: Breaching peer review confidentiality

One-sided debate manipulation: Preventing authors from defending themselves while publicly attacking their work

Methodological errors: The RNase and lot size criticisms appear invalid

Data misrepresentation: His own group appears to have manipulated data presentation (the 10x magnification issue)
Unvalidated methods: Proposing alternative methods without proper validation
Pattern repetition: Using the same tactics against multiple research groups
Circumventing journal processes: Publishing preprints when formal responses don't go his way
Ad hominem attacks: Using inflammatory language that violates professional standards
This is not legitimate scientific criticism - this is a coordinated campaign to suppress research findings through procedural manipulation and ethics violations. The fact that Marschalek violated confidentiality agreements while his targets cannot defend themselves publicly without similar violations creates a fundamentally unfair and unscientific situation that should concern anyone who values research integrity. Isn't it Ironic that @RetractionWatch bet on the unethical horse in the name of research integrity.

Why is @ellie_kincaid so silent on these threads? Cat got your tongue?
Nov 21 11 tweets 4 min read
Hey @ellie_kincaid , This is poor journalism.

You left the ID of your anon "Reviewer" in the PDF document you sent us.

Were you too lazy to see this person has BioNtech Funding? Maybe that explains why they don't understand we used 500-1000X excess RNase A?

Get a helmet. Stepping on this many rakes can do some damage.
anandamide.substack.com/p/retraction-w…

@SenRonJohnson @weldeiry @RetsefL @DrJBhattacharya @MartyMakary @KUPERWASSERLAB @RWMaloneMD @RobertKennedyJr @JesslovesMJK @DJSpeicherImage HT @sudokuvariante for the file forensics.
Nov 15 5 tweets 2 min read
This experiment clearly shows the mechanism of action that is at play and why the DNA is still in the vaccines and why the regulators are missing it.
@weldeiry @RetsefL @KUPERWASSERLAB @DrJBhattacharya @RobertKennedyJr @RWMaloneMD @MartyMakary
@JesslovesMJK
@CharlesRixey
@joerogan It comes back to Sutton et al.
DNaseI cannot process RNA/DNA hybrids.
After you make RNA from DNA it will be hybridized to the DNA.

pmc.ncbi.nlm.nih.gov/articles/PMC12…
Nov 7 6 tweets 3 min read
Calling all plebs and HVAC experts.

You can BLAST this sequence and discover what's in a Monkey pox vaccine.
@KUPERWASSERLAB @weldeiry

mega.nz/file/FZoniBzD#… Use NCBI nucleotide BLAST.
blast.ncbi.nlm.nih.gov/Blast.cgi
Oct 21 12 tweets 3 min read
A frame work for a new "Peer to Peer" peer review system using @primal_app and Bitcoin. Image 1)Turn your PDF into a PNG file
2)Post onto to Nostr via @primal_app
3)shasum -a 256 your PNG file.
4)Open datacarriersize=200B
5)Submit Primal/Nostr link + Sha256 Hash to Bitcoin through OP_RETURN via Mara SlipStream

@jimmysong @PeterTodd_S_CTO @ToneVays @adam3us @lopp
Oct 13 4 tweets 2 min read
@luijsterburglab @MaryanneDemasi @jeffreyatucker @TonyNikolic10 @ClareCraigPath @JesslovesMJK @dragonfishy @RWMaloneMD @weldeiry @Humanspective @DrEliDavid @kenjaques You are clueless to the fact that PolyA/T also hits RIGI and Pol3.

The proper control for Process 1 (PCR) vs Process 2 (Dam methylated) is what you have been shown but still can’t Grok. Image @luijsterburglab @MaryanneDemasi @jeffreyatucker @TonyNikolic10 @ClareCraigPath @JesslovesMJK @dragonfishy @RWMaloneMD @weldeiry @Humanspective @DrEliDavid @kenjaques Note the asterisk and P values.

Still having a hard time? Image
Oct 5 12 tweets 4 min read
🔥New PrePrint out🔥
Hyper-stimulatory N⁶-methyladenine (m6A) in residual SV40 plasmid DNA in mRNA vaccines.
@RetsefL @weldeiry @RWMaloneMD @RobertKennedyJr @KMilhoanMDPhD Image Oxford Nanopore Sequencing reveals Pfizer didnt use a Dam knock out E.coli strain and the resulting plasmid DNA contamination is hyper stimulatory to the cGAS-STING pathway.
zenodo.org/records/172724…
Oct 3 8 tweets 3 min read
Feline Friday is cooking up more Nanopore reads and they are damning. Image You asked for it. This is an Algo experiment.
Does the Feline Friday crowd have more reach. Aka the internet loves cats.

Here are some long NanoPurr reads.

The Topic…
“Since Pfizer Linearizes the plasmid, it’s not replication competent”..
Amirite?
Oct 1 6 tweets 4 min read
Are you frustrated with the schizo behavior of @POTUS on the vaccines.

Me too.

The Ping Pong is intentional.
One week, Ron Johnson
Then Kirk.
Then ACIP
Then space Vax out/Tylenol
Then demand Pfizer cough up $70B in discounts.

You are witnessing
The Crossruff. What is a crossruff?

It’s a bridge technique (card game) to maximize points in a pre-negotiated game where you have asymmetric strength in different partners.

If you understand the crossruff,
You’ll begin to see what’s happening.

It’s cold, calculated and maximizing of political gain.Image
Sep 24 5 tweets 2 min read
Loaded up a 1300 pore chip.

A low concentration psilocybe genome and some Pfizer filler. Had to break in a new ONT sequencer. Image
Sep 10 6 tweets 2 min read
Our paper is now the #1 article from Autoimmunity according to Altmetrics.
Top 99% for all 29M articles they track.
tandfonline.com/doi/full/10.10…Image Broad geographic interest.
tandf.altmetric.com/details/181158…Image
Sep 6 24 tweets 9 min read
Our DNA contamination Paper is now live and peer reviewed.

The most valuable part of this process was actually the peer review.

I hope the Journal puts them public as every fact checker complaint was raised and traversed in that process.

And I’m certain the retraction mob will be harassing the journal with those tired claims, thus having the review public would save them a lot noise. More discussion on how to view this paper in light of the preprint from Slovakia Image
Sep 3 6 tweets 3 min read
Finally, a cannabis adverse events database.
Long overdue to end all the receipt-free speculation.
Note the average age is 56y/o suggestive of polypharmacy and p450 collisions.
@Aelxberenson Gonna have to rename that book

"Tell your Boomers, the truth about cannabis"

link.springer.com/article/10.118…Image People over 50 are on more blood thinners and other meds that rely on CYP2C9/19 and CYP3A4.
Note there are more Adverse events for products with high CBD/THC ratios related to Hallucinations, Dyspenia, Anxiety etc. That is likely a p450 collision as CBD isnt psychoactive in this way.Image
Aug 3 6 tweets 2 min read
Flattered by the review.
An important pre-requisite is @jackmallers Madeira talk on time chains.



This does lead to a larger discussion around how the deflationary benefits of AI will flow into scarce and secure assets like BTC.

The reason BTC is growing faster than AI.. Is that it is actually an AI in disguise.
One has to widen their view of intelligence beyond anthropomorphic forms of intelligence and use a universal metric of intelligence as anything that creates value and perpetuates.

Under this view of intelligence being a value creation and perpetuation-
Jul 13 5 tweets 2 min read
File Under-

“It does not need to InTeGrAtE to cause cancer”

@Docjohnc @NicHulscher @Double_Christ @JesslovesMJK Image Extracellular DNA and Cancer
cell.com/trends/cancer/…Image
Jul 1 4 tweets 2 min read
In 20 years when your kids ask why you didn't hedge the hyper-inflationary Fiat system.....
You can't say "there weren't any obvious signs". Image
Jun 24 7 tweets 3 min read
While the Pharma funded fact checkers swear the SV40 isn’t there…
BioNTech quietly files with the EMA admitting it’s in fact there.

They might clean it up.
Might not. Image
Image
Image
Image
Notice how they claim the SV40 elements are non-utilized.

That’s bullshit.
They are the promoter for the kanamycin resistance
Jun 3 4 tweets 2 min read
Japan at 3.6 shots per capita with more mRNA deaths than all prior vaccines over 47 years.
Most mRNA vaxxed country in the world.

jmaj.jp/detail.php?id=… A sign of a blood sucking Darwin Award where you sacrifice your youth to save the elderly.
Absolute generational parasites.
Statism on steroids. Image
May 23 7 tweets 2 min read
Are there genetic predispositions to vaccine induced thrombosis, clotting and amyloidogenesis? Image open.substack.com/pub/anandamide…
May 14 5 tweets 2 min read
🔥Scientific Misconduct and Plagiarism from Dr. Richard Fleming🔥.

The Journal has been made aware of Richard Fleming plagiarizing our primer sequences and not citing them.

I normally wouldn't care. They are open source but the same primer table in @DJSpeicher et al contained the SV40 primer sequences he NEVER used while still claiming SV40 was not detected. He claimed this 3 times but never actually tested for SV40.

@P_J_Buckhaults
@MaryanneDemasi
@JesslovesMJK
@CanningPharm
@Double_Christ
@dystopian_DUImage Irony.. Fleming was bragging about his work was peer reviewed.
Or Peer stolen, twisted and obfuscated... but to what ends? Who does Fleming work for and did he copy these sequences and refuse to cite the work while spreading non sense about the SV40 sequences? Image