Kasper Planeta Kepp Profile picture
Computational biochemistry & biomedicine; protein evolution, disease modeling. Ph.D. Lund; Postdoc Yale & Stanford.

Aug 25, 2021, 8 tweets

This Danish article surprisingly argues for boosters ("3rd shot") for *full* population, due to: 1) waning antibodies 2) "looks like vaccinated people in Israel, where they vaccinated long before us, are getting sick again."

A few comments below.
1/6
dr.dk/nyheder/viden/…

Claim 1: Antibodies are *expected* to fall after infection/vax. But t-cells/B-cells remain. Waning antibodies is *not* equivalent to waning immunity.
2/6



Claim 2: "People previously vaccinated are getting sick again." This claim is based on early reports from Israel.
However the actual data as other places: >85% VE for disease, & VE waning non-significant. Vaccines work!
3/6


Boosters for vulnerable is desirable before Winter.
But for ethical & epidemiological reasons, most experts think boosters for healthy non-risk pop is *not* warranted.

The particular expert in the article disagrees, but Ab waning & Israel data do not justify this i.m.o.

4/6

Expert statements:








Also, the article is written as if just a matter of time before all need boosters (the interviewed is part of the panel deciding). 🧐
Next time @DRNyheder conveys a scientific minority opinion on a topic with evident complexity & huge special interests, show #balance please.

6/6

Just for perspective: 99% of deaths were 50+.
The marginal extra-effect on deaths/hosp of mass-applying boosters to millions of healthy young/adults who *already* had 2 shots becomes unethical due to misplaced focus vs. other things killing people (incl. covid elsewhere).

Risk is exponential in age (99% deaths 50+) -this fact seems to still confuse some people proposing policy.

Reducing deaths & hosp this Winter by boosting old & vulnerable very important.

But those arguing for mass-boosting young/adults don't seem to understand exp functions.

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