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Kasper Planeta Kepp Profile picture
@KasperKepp
Aug 25, 2021 • 8 tweets • 7 min read • Read on X
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This Danish article surprisingly argues for boosters ("3rd shot") for *full* population, due to: 1) waning antibodies 2) "looks like vaccinated people in Israel, where they vaccinated long before us, are getting sick again."

A few comments below.
1/6
 dr.dk/nyheder/viden/…
Claim 1: Antibodies are *expected* to fall after infection/vax. But t-cells/B-cells remain. Waning antibodies is *not* equivalent to waning immunity.
2/6


Claim 2: "People previously vaccinated are getting sick again." This claim is based on early reports from Israel.
However the actual data as other places: >85% VE for disease, & VE waning non-significant. Vaccines work!
3/6

Boosters for vulnerable is desirable before Winter.
But for ethical & epidemiological reasons, most experts think boosters for healthy non-risk pop is *not* warranted.

The particular expert in the article disagrees, but Ab waning & Israel data do not justify this i.m.o.

4/6
Expert statements:








Also, the article is written as if just a matter of time before all need boosters (the interviewed is part of the panel deciding). 🧐
Next time @DRNyheder conveys a scientific minority opinion on a topic with evident complexity & huge special interests, show #balance please.

6/6
Just for perspective: 99% of deaths were 50+.
The marginal extra-effect on deaths/hosp of mass-applying boosters to millions of healthy young/adults who *already* had 2 shots becomes unethical due to misplaced focus vs. other things killing people (incl. covid elsewhere).
Risk is exponential in age (99% deaths 50+) -this fact seems to still confuse some people proposing policy.

Reducing deaths & hosp this Winter by boosting old & vulnerable very important.

But those arguing for mass-boosting young/adults don't seem to understand exp functions.

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More from @KasperKepp

Kasper Planeta Kepp Profile picture
Nov 24, 2023
Since IndieSAGE now tries to revise history to appear mainstream, a short thread on what they actually were, what they did, who they were associated with, and why it matters for science and our democracy. /1
First of all, IndieSAGE is a zerocovid group: It recommended zerocovid in England as late as Aug 2020 and members supported zerocovid even into 2021. Trying to revise history, claiming "advice was largely in line with SAGE" is thus misinformation. /2


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Second, IndieSAGE is closely affiliated with World Health Network led by Yaneer Bar-Yam and Eric Feigl-Ding. The appendix with ~130 WHN co-signatures is a revelation to anyone interested in pandemic Twitter and lists all their partner ZC groups /3
thelancet.com/journals/lance…
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Read 14 tweets
Kasper Planeta Kepp Profile picture
Sep 17, 2023
Below a list of misinformation from @DrEricDing from the zero-covid group World Health Network who has been repeatedly debunked by others, documenting the scientific problem of @peterhotez's endorsement. whn.global/meet-our-team/
1. Danish @SSI_dk debunking misinformation on Danish covid numbers. cphpost.dk/?p=131358
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2. @WHO debunking misinformation about monkeypox, incl. a "pandemic declaration" by the similarly sounding "World Health Network" (a zerocovid group).

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Read 12 tweets
Kasper Planeta Kepp Profile picture
Aug 31, 2023
Just noting that the editor has a company selling N95 masks so for legal reasons and in democratic/public interest it may be fair to label the below advocating for intense post-pandemic use of HCW masks as a commercial / marketing advertisement.
co2radical.com.au/co2-monitoring…


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Other views from same editor:
1) vaccines "last resort" that you "don't want to have to use" 2) chronic disability a "catastrophe for our species"; 3) "they killed the last queen by infecting her with covid"; 4) amplifying debunked Mpox fake news.




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The editors of the "John Snow Project" were systematically involved in spreading monkeypox misinformation, incl. the fake news from Spain implicating community transmission that was debunked by e.g. @kallmemeg @MarionKoopmans
@benryanwriter @SaskiaPopescu




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Read 4 tweets
Kasper Planeta Kepp Profile picture
Jun 30, 2023
@US_FDA is likely to approve #lecanemab next week after advisors "voted" for efficacy. Yet while statistically significant, this effect is very small (2.5%) & below clinically meaningful (MCID) (figure by my dear colleague prof. Poul Høilund-carlsen). /1
https://t.co/DmVr64jHvQcontent.iospress.com/articles/journ…
Three papers on minimal important difference exist; they all set CDR-SB at >1. https://t.co/gbeJU92EUB https://t.co/dUeSzdGrr8 Unfortunately Van Dyck et al. did not cite any of them when they claimed this regarding their 0.45 effect: /2 https://t.co/3uu5wI2ytPpubmed.ncbi.nlm.nih.gov/36641605/
pubmed.ncbi.nlm.nih.gov/31417957/
ncbi.nlm.nih.gov/pmc/articles/P…
Also, the effect is very heterogeneous, raising the concern that the groups could not be treated as one in the prespecified endpoint, which would then be statistically inappropriate. A small very heterogeneous effect increases the risk of bias. /3
Read 10 tweets
Kasper Planeta Kepp Profile picture
Jun 16, 2023
Jeg havde egentlig lagt pandemidebatten bag mig, men nødt til at reagere, da det her er Alternativets kampagneleder. Skolelukninger er nok det mest afklarede spørgsmål overhovedet i den pandemiske debat -holdning i strid med lang række studier og udmeldinger fra organisationer.
Konsekvenser:
1) Scale of education loss ‘nearly insurmountable’ @UNICEF unicef.org/press-releases…

2) 15% flere børn ikke i stand til at læse simpel tekst
unicef.org/press-releases…

3) 39 milliarder tabte måltider, mange børn mistet vigtigste ernæringskilde
dlvr.it/RryRW8
4) World Bank: estimeret 17 tusind milliarder💲 tabt livsindtjening
worldbank.org/en/news/press-…

5) PNAS: Social slagside, hjemmeskoling hindrede ikke:
pnas.org/content/118/17…

6) Nature Human Behavior Metaanalyse: Læringstab m. social slagside
nature.com/articles/s4156…
Read 7 tweets
Kasper Planeta Kepp Profile picture
Jun 1, 2023
I really hope that we can identify new preventable dementia causes and I consider certain infections to be plausible, although not proven, risk factors of dementia. However, this preprint and associated tweet (with 13,000 likes!) does not convince me. /1
The studied effect (Figure 3) is a slope-difference measure (regression discontinuity) of dementia risk of people eligible or not for vaccination. Such estimates require high precision, since slopes are very sensitive, but the data are very scattered. /2
Furthermore, the slope on the right where effect is seems uncertain, and while probably reflecting a higher weighting of data close to the cutoff as common in such designs, it does not seem better than a single line (zero hypothesis of no effect) (lines removed to the right). /3 Image
Read 7 tweets

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