Turning a Corner in ME/CFS Research: mdpi-res.com/d_attachment/m… #pwME #LongCovid
ME/CFS is a multi-system disorder, with dysregulation of the HPA axis and of metabolism of the central nervous system and of body systems generally. The range of abnormal responses includes:
1/
-alteration of autonomic nervous system function
-lasting adaptations in energy metabolism and the immune response
-orthostatic intolerance with reduction in cerebral blood flow on tilt testing
-variations in cortisol levels associated with increased fatigue. #pwME
2/
-disorganized circadian rhythms
-increased immune system activation as shown for example by increased pro-inflammatory cytokines and prolonged inflammatory responses
-alterations in muscle anaerobic threshold
-abnormal recovery after activity with post-exertional malaise
#pwME
3/
-central sensitization
-changes in grey and white matter in the brain
-anatomical, physiological and electrical abnormalities in the brain
-chronic activation of the immune system, including autoantibodies directed at the central and autonomic nervous systems #pwME
4/
-impaired energy metabolism with associated oxidative stress
-dysregulation of the autonomic nervous system
-abnormalities of the gut microbiome
#pwME
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