1/ Comparison of immune responses to Pfizer, Moderna, & J&J vaccines over 8 months post-vaxx.
Neutralizing antibodies:
- Pfizer: peaked high, then ⬇️ over time
- Moderna: peaked highest, then ⬇️ over time
- J&J: lower peak, but stable (?⬆️)over time
nejm.org/doi/full/10.10…
2/ Another look at neutralizing antibody responses for Pfizer, Moderna, and J&J vaccines over time:
3/ With all three vaccines, functional antibody responses (antibody-dependent cellular phagocytosis & antibody-dependent complement deposition) were stable over time:
4/ Those who got Pfizer/Moderna vaccines had ⬇️antibodies over time to early WA1 variant and to Alpha, Beta, Delta variants:
5/ Those who got J&J vaccine antibodies were stable/⬆️ over time to early WA1 variant and to Alpha, Beta, Delta variants:
6/
7/ CD4+ T-cell & CD8+ T-cell responses to Pfizer, Moderna, J&J vaccines are pretty stable over time:
8/ CD4+ T-cell & CD8+ T-cell responses to Pfizer, Moderna, J&J vaccines by variant over time:
9/ In summary:
- High peak antibody responses to Pfizer & Moderna vaccines followed by ⬇️
- Moderna generally elicited higher antibody titers than Pfizer
- J&J elicited lower initial antibody responses, but these were stable over time
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