Thread by @celinegounder

1/ Comparison of immune responses to Pfizer, Moderna, & J&J vaccines over 8 months post-vaxx.

Neutralizing antibodies:
- Pfizer: peaked high, then ⬇️ over time
- Moderna: peaked highest, then ⬇️ over time
- J&J: lower peak, but stable (?⬆️)over time

nejm.org/doi/full/10.10…

2/ Another look at neutralizing antibody responses for Pfizer, Moderna, and J&J vaccines over time:

3/ With all three vaccines, functional antibody responses (antibody-dependent cellular phagocytosis & antibody-dependent complement deposition) were stable over time:

4/ Those who got Pfizer/Moderna vaccines had ⬇️antibodies over time to early WA1 variant and to Alpha, Beta, Delta variants:

5/ Those who got J&J vaccine antibodies were stable/⬆️ over time to early WA1 variant and to Alpha, Beta, Delta variants:

6/

7/ CD4+ T-cell & CD8+ T-cell responses to Pfizer, Moderna, J&J vaccines are pretty stable over time:

8/ CD4+ T-cell & CD8+ T-cell responses to Pfizer, Moderna, J&J vaccines by variant over time:

9/ In summary:
- High peak antibody responses to Pfizer & Moderna vaccines followed by ⬇️
- Moderna generally elicited higher antibody titers than Pfizer
- J&J elicited lower initial antibody responses, but these were stable over time