1/ Comparison of immune responses to Pfizer, Moderna, & J&J vaccines over 8 months post-vaxx.
Neutralizing antibodies:
- Pfizer: peaked high, then ⬇️ over time
- Moderna: peaked highest, then ⬇️ over time
- J&J: lower peak, but stable (?⬆️)over time
2/ Another look at neutralizing antibody responses for Pfizer, Moderna, and J&J vaccines over time:
3/ With all three vaccines, functional antibody responses (antibody-dependent cellular phagocytosis & antibody-dependent complement deposition) were stable over time:
4/ Those who got Pfizer/Moderna vaccines had ⬇️antibodies over time to early WA1 variant and to Alpha, Beta, Delta variants:
5/ Those who got J&J vaccine antibodies were stable/⬆️ over time to early WA1 variant and to Alpha, Beta, Delta variants:
6/
7/ CD4+ T-cell & CD8+ T-cell responses to Pfizer, Moderna, J&J vaccines are pretty stable over time:
8/ CD4+ T-cell & CD8+ T-cell responses to Pfizer, Moderna, J&J vaccines by variant over time:
9/ In summary:
- High peak antibody responses to Pfizer & Moderna vaccines followed by ⬇️
- Moderna generally elicited higher antibody titers than Pfizer
- J&J elicited lower initial antibody responses, but these were stable over time
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1/ A new report from the American Association for Cancer Research @AACR finds that excessive alcohol use is a risk factor for at least 6 cancers.
with @GayleKing @vladduthiersCBS @tonydokoupil
2/ Heavy drinking is associated with an increased risk of:
🔹head & neck cancer
🔹esophageal cancer
🔹stomach cancer
🔹liver cancer
🔹colorectal cancer
🔹breast cancer
3/ Drinking during pregnancy can also increase the risk of leukemia later in childhood.
At least 5% of cancers are attributable to alcohol.
1/ Yesterday, the @WHO declared mpox a public health emergency of international concern (PHEIC).
This is the 2nd time in 2 years that the WHO has declared a PHEIC for mpox.
with @vladduthiersCBS on @CBSMornings
2/ There have already been more than 17K cases in Africa so far this year – more than the total for all of last year.
3/ @WHO announces a Public Health Emergency of International Concern (PHEIC) when there is a significant risk to global health & it requires an internationally coordinated response.
A PHEIC:
🔹helps marshal funding for a public health response
🔹pressures governments to act
2/ A new study published in the JAMA Health Forum yesterday found that:
🔹mask requirements & vaccine mandates were associated with ⬇️ deaths
🔹prohibitions on vaccine or mask mandates were associated with ⬆️death rates
1/ New Hope Against Dementia: study says singles vaccine also appears to delay onset of dementia
with @CBSMornings' @tonydokoupil @AdrianaDiaz @nateburleson
2/ A study published yesterday in Nature Medicine found that the new Shingrix vaccine was more protective than the old Zostavax vaccine in delaying dementia.
The Zostavax shingles vaccine was discontinued after the Shingrix vaccine was approved.
1/ Tick-borne infections are on the rise around the country
with @CBSMornings @GayleKing @tonydokoupil @nateburleson
2/ A unique collaboration among hunters,
the Texas Parks & Wildlife Department @TPWDnews,
& researchers at @Baylor University
is helping to map what tick-borne diseases can be found where.
3/ Lyme disease is the most common tick-borne infection in the US, but it's far from the only one. hopkinslymetracker.org