When you Warp Speed your codon optimizations and forget to look to at quadruplex G formation.
These mRNA Vaccines should be considered Pro-Drugs, where proof of the final drug is measured, not assumed.
osf.io/bcsa6/
So Molbio folks like to Jack the expression of genes sadly assuming that more is better.
To do this they add strong beta globin promoters and swap the synonymous bases in the codons out with more human like codons.
This is called codon optimization.
There are consequences
First consequence is you tend to shift the GC content of the mRNA significantly when you do this.
36%->61%.
But one should question why your believe the virus ,which is already adapted to its host) needs this tweak?
It doesn’t come risk free.
So these codon optimizations generate quadruplex G formations in the vaccines that don’t exist in the virus.
Lots of them.
What are quadruplex Gs or G4’s.
They are a different form of base pairing known as Hoogstein base pairing. Thinking reverse coiled helical phone cable knots.
Think Telomeres. Think gene regulation.
The preprint goes into detail on the biological significance of G4’s in viral biology.
But the take home message, is the mRNAs are not bio equivalent to the virus and there is no evidence of what these mRNA synthesize in humans. Odds are it’s very error prone.
Some choice selections regarding SEB.
Vax based inflammation
ahajournals.org/doi/10.1161/ci…
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