1/ The current mRNA vaccines use an abnormal substitution for uridine; every U is replaced with m1Ψ (N1-methylpseudouridine). This synthetic substitution was made to increase mRNA stability, reduce immunogenicity, and increase expression. But what are the health effects of m1Ψ?
2/As an example, the human protein EMG1 is a pseudouridine N(1)-methyltransferase that methylates pseudouridine at position 1248 in 18S rRNA. It’s also involved in 40S ribosomal subunit biogenesis. Will m1Ψ from the vaccine inactivate this enzyme?
genecards.org/cgi-bin/carddi…
3/ If so, what cell types will this inactivation take place, and for how long? What are the implications for ribosomal assembly and protein synthesis in these cells?
4/ It’s known that genetic alterations to EMG1 function result in severe disease (Bowen Conradi syndrome in infants)
genecards.org/cgi-bin/carddi…
5/ And although m1Ψ-induced inhibition of EMG1 from the vaccine may be temporary and/or localized to certain tissues, the overall impact to fertility, embryonic development, childhood development, and adult human health have not been thoroughly studied.
7/In addition to the above, this article presents more problems associated with skewed GC content due to codon optimization, and the effects of m1Ψ on RNA secondary structure, G-quadruplex formation, and associated interactions with RNA-binding proteins.
osf.io/bcsa6/
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