Thread by @DrEricDing

💡New VACCINE RANKING of ability to neutralize #Omicron—Moderna appears to be the strongest against Omicron in this study, but still big drop. Pfizer next best (but we know infection efficacy is 30-34%), AstraZeneca & Sinopharm poor. J&J & Sputnik = zero.🧵biorxiv.org/content/10.110…

2) Natural infection immunity is on the left … “convalescent” = practically no neutralization against #Omicron in this study by itself without vaccine.

3) Meanwhile for SinoVac —one of the world’s most widely used vaccines, doesn’t provide sufficient antibodies to neutralize the #omicron variant, said 🇭🇰 researchers. But a 3rd shot booster seemed up help. bloomberg.com/news/articles/…

4) The other recent large South Africa 🇿🇦 study reports 2 shots of Pfizer offered 33% VE against symptomatic infection; and 70% against hospitalization (much lower than the 90s prior). We need boosters.

5) in an AT study of neutralization, they also found 2 shots of AstraZeneca was pretty weak. But also found Moderna weak—but in their population, Moderna folks had a 4 month gap between shots. But mixing AZ+Pfizer seems half decent. Past infection alone little help! (Lower left)

6) This above Austrian neutralization study matches the drop in VE seen in the UK — where 2x shots of Oxford-AstraZeneca has little benefit without a booster, and 2 shots of Pfizer slightly better but still only in the low to mid 30% VE without a booster.

7) But a 3rd shot (Pfizer booster) after 2 shots of AZ puts one back up to 71.4% VE against symptomatic #Omicron disease after 2 weeks after 3rd shot. This is good news at least. #GetBoosted

8) With 2 shots of Pfizer, the VE starts at 88% between 2-9 weeks after the 2nd shot. Good, but it quickly drops to 48.5% by weeks 10-14 after 2 shots. Then drops and to 31% by 15-19 weeks. Then it hovers at 36.6% at 20-24 weeks. Then 34.2% at 25+ weeks. But 75.5% with booster!👀

9) The top study also compared the key monoclonal antibody drugs (the major drug ones have a name on the left) — several of them have little to no detectable effects against #Omicron. This is bad.

10) Which are the monoclonal antibody drugs in trouble against #Omicron? These:

11) The Sputnik V vaccine has entered the chat… their research institute Gamaleya Center has put out a statement saying the study reported above was “not representative” and they will have new results in a few days.

12) it’s now clear that #Omicron is spreading so fast because it both **evasive** as well as highly contagious — new study finds the virus replicates **70x faster in one’s windpipe** than the original Wuhan virus. 👇

13) the airborne nature of the coronavirus cannot be overlooked— in fact— stopping airborne transmission is just as important and vaccinating people. And ventilation and air disinfection could even be more effective - because it is agnostic to vaccine willingness / politics!