Graham Pechenik Profile picture
IP law & strategy for psychedelics ventures & emerging tech || Registered patent attorney || UCSD biochem + cognitive neurosci || NYU Law || SF/Oakland native

Dec 30, 2021, 9 tweets

New psychedelic inventions?

∰ Field Trip—tryptamine prodrugs

∰ Greenway DNA—personalized psychedelic treatment

∰ Small Pharma—deuterated DMT

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Field Trip $FTRP: “Tryptamine Prodrugs”

Application covers diacid hemiester prodrugs of tryptamines & isotryptamines, eg, psilocin, 4-HO-DET, 4-HO-DiPT, & 4-HO-MiPT

Head twitch response & pharmacokinetics in rats & humans with 4-hemiglutarate & 4-hemisuccinate of 4-HO-DiPT

2/9

Is Field Trip $FTRP FT-104 a prodrug of 4-HO-DiPT?

In “Use in Treatment,” app discloses intramuscular & subcutaneous injection or oral tablet administration of:

N,N-isopropyltryptamine-4-glutarate (4-hemiglutarate of 4-HO-DiPT)

& subcutaneous “injectable formulation kit”

3/9

Is Field Trip $FTRP FT-104 a prodrug of 4-HO-DiPT?

“FT-104’s pharmacological profile is similar to psilocybin”

“FT-104 duration is two to three hours, substantially shorter than psilocybin”

More details in Field Trip’s corporate presentation:

meetfieldtrip.com/home/default.a…

4/9

4-HO-DiPT (iprocin) is a psilocin homolog

Shulgin in TiHKAL:

“I truly doubt that there is another psychedelic drug, anywhere, that can match this one for speed, for intensity, for brevity, and sensitive to dose, at least one that is active orally”

erowid.org/library/books_…

5/9

“To be on a trip & then to be back pretty much in two hours & really baseline in another hour? Most unusual. If there will ever be an acceptance of drugs such as these, in a psychotherapeutic context, a short duration is of extreme value to both the patient & the therapist.”

6/9

Greenway DNA: “Methods & Systems for Providing a Personalized Treatment Regimen Using Cannabinoid or Psychedelic Compounds”

Providing “personalized psychedelic compound treatment regimen” to patient based on genotypes of single nucleotide polymorphisms from genetic testing

7/9

Small Pharma: “Deuterated N,N-Dimethyltryptmine Compounds”

“compositions and methods which enable a finely tuned single dose to maintain a patient in full dissociation from the external world, referred to herein as ‘DMT space,’ for a therapeutically optimised duration”

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Field Trip: appft.uspto.gov/netacgi/nph-Pa…

Greenway DMT: appft.uspto.gov/netacgi/nph-Pa…

Small Pharma: appft.uspto.gov/netacgi/nph-Pa…

Follow psychedelic patents with @PsilocybinAlpha Patent Trackers:

psilocybinalpha.com/data

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