Graham Pechenik Profile picture
Dec 30, 2021 9 tweets 8 min read Read on X
New psychedelic inventions?

∰ Field Trip—tryptamine prodrugs

∰ Greenway DNA—personalized psychedelic treatment

∰ Small Pharma—deuterated DMT

1/9
Field Trip $FTRP: “Tryptamine Prodrugs”

Application covers diacid hemiester prodrugs of tryptamines & isotryptamines, eg, psilocin, 4-HO-DET, 4-HO-DiPT, & 4-HO-MiPT

Head twitch response & pharmacokinetics in rats & humans with 4-hemiglutarate & 4-hemisuccinate of 4-HO-DiPT

2/9
Is Field Trip $FTRP FT-104 a prodrug of 4-HO-DiPT?

In “Use in Treatment,” app discloses intramuscular & subcutaneous injection or oral tablet administration of:

N,N-isopropyltryptamine-4-glutarate (4-hemiglutarate of 4-HO-DiPT)

& subcutaneous “injectable formulation kit”

3/9
Is Field Trip $FTRP FT-104 a prodrug of 4-HO-DiPT?

“FT-104’s pharmacological profile is similar to psilocybin”

“FT-104 duration is two to three hours, substantially shorter than psilocybin”

More details in Field Trip’s corporate presentation:

meetfieldtrip.com/home/default.a…

4/9
4-HO-DiPT (iprocin) is a psilocin homolog

Shulgin in TiHKAL:

“I truly doubt that there is another psychedelic drug, anywhere, that can match this one for speed, for intensity, for brevity, and sensitive to dose, at least one that is active orally”

erowid.org/library/books_…

5/9
“To be on a trip & then to be back pretty much in two hours & really baseline in another hour? Most unusual. If there will ever be an acceptance of drugs such as these, in a psychotherapeutic context, a short duration is of extreme value to both the patient & the therapist.”

6/9
Greenway DNA: “Methods & Systems for Providing a Personalized Treatment Regimen Using Cannabinoid or Psychedelic Compounds”

Providing “personalized psychedelic compound treatment regimen” to patient based on genotypes of single nucleotide polymorphisms from genetic testing

7/9
Small Pharma: “Deuterated N,N-Dimethyltryptmine Compounds”

“compositions and methods which enable a finely tuned single dose to maintain a patient in full dissociation from the external world, referred to herein as ‘DMT space,’ for a therapeutically optimised duration”

8/9
Field Trip: appft.uspto.gov/netacgi/nph-Pa…

Greenway DMT: appft.uspto.gov/netacgi/nph-Pa…

Small Pharma: appft.uspto.gov/netacgi/nph-Pa…

Follow psychedelic patents with @PsilocybinAlpha Patent Trackers:

psilocybinalpha.com/data

9/9

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More from @calyxlaw

Jan 19, 2023
What happens when two companies’ patents both cover the same drug?

Reunion Neuroscience’s lead RE104 = isoprocin glutarate, a prodrug of 4-OH-DiPT

Reunion $REUN has a granted patent claiming it

Today, Mindset Pharma $MSET received a notice of allowance on claims to it too

1/7
Field Trip $FTRP (the original applicant) obtained its patent on RE104 (then FT-104) after first w/drawing it from issuance to ensure examiner reviewed Mindset’s apps

Mindset’s were filed first, but only published after Field Trip’s app was allowed

Patent was allowed again

2/7
After Field Trip received its patent, Mindset filed a continuation application adding new claims

One of those claims is to isoprocin glutarate, Field Trip’s prodrug of 4-OH-DiPT

Today, that claim was allowed

Mindset paid the issue fee immediately

A patent will issue soon

3/7
Read 8 tweets
Jun 22, 2022
MDMA + LSD = a patentable invention?

According to the USPTO, yes

Today—MindMed $MNMD granted a US patent, with claims to:

“A composition comprising an empathogen/entactogen and a psychedelic in the same single oral dosage form.”

Along with methods of using it

🍬🤸🏻

1/9
What’s the patentable invention?

According to MindMed, that the entactogen & the psychedelic are in “the same single oral dosage form”

By contrast: “Recreational users use MDMA & LSD in separate dosage forms.”

A single dosage form ≠ “a single session of substance abuse”

2/x
But what about all the prior art on candyflipping?

Indeed—@_PortaSophia filed a third-party submission to challenge MindMed’s claims, citing 20 references

However, MindMed already split off this sister app, under accelerated examination program

It was allowed 1 week later

3/9
Read 9 tweets
Feb 2, 2022
All your vapes are belong to us?

New patent granted—“Delivery System for Ayahuasca-Like Substances”

Claims DMT vapes, 5-MeO-DMT vapes, & 2C-B vapes

These claims can be immediately enforced

1/6
The patent claims:

“A device for the delivery of a substance comprising:

a chamber comprising at least one vaporizable formulation wherein the vaporizable formulation comprises the substance and wherein the substance comprises one or more of”

DMT, 5-MeO-DMT, or 2C-B

2/6
The application was first filed as a provisional in July 2020

Did DMT vape pens exist in the prior art before the priority date?

This @doubleblindmag article was first published on Feb. 5, 2020:

3/6
doubleblindmag.com/are-dmt-vape-p…
Read 6 tweets
Dec 31, 2021
Patentable pharmahuasca “kits of parts”?

New PCT app published: “Compositions & Kits of Parts Comprising N,N-DMT & Harmine & Their Use in Therapy”

“An alternative to ayahuasca that solves the problems of side effects…is pharmahuasca, also known as synthetic ayahuasca”

1/4
Applicant is University of Zürich, w inventors Dario Dornbierer, Davor Kosanic, & Milan Scheidegger

All are founders at Reconnect Labs: “a Spin-off of the University of Zürich…setting standards for a novel kind of ethical drug development company”

reconnect-foundation.org/reconnect-labs/

2/4
The PCT app claims:

–a “kit of parts” of DMT & harmine

–a composition of DMT & harmine

-their use to treat psychiatric disorders

None were found inventive

3/4
Read 4 tweets
Dec 29, 2021
New psychedelic inventions?

⁂ Phil Wolfson/KRF—ketamine for postpartum symptoms

⁂ Psilo Scientific—psychoactive & psychedelic fungus extraction

⁂ Cognigenics—5-HT2A “cognitive upgrade”

⁂ Liechti—MDMA response prediction

⁂ Small Pharma—DMT-type compound synthesis

1/14
…and more new psychedelic inventions?

⁂ Ixtlan—psilocybin for Alzheimer’s

⁂ Spirify—hydroxynorketamine analogs

⁂ Guangzhou Dazhou Biomedicine—transdermal ketamine

⁂ Disruption Labs—nanoparticle compositions

⁂ Daniel Lilly—“medicinal food products” with psilocybin

2/14
Ketamine Research Foundation (KRF)—“Ketamine for the Treatment of Postpartum Symptoms & Disorder”

First inventor Phil Wolfson

“treatment of all forms of emotional and psychological symptoms and disorders related to childbirth and its aftermath”

patentscope.wipo.int/search/en/deta…

3/14
Read 14 tweets
Nov 20, 2021
Novel ketamine + psilocybin inventions?

New patent applications published:

𝔎 Celon Pharma—pulmonary administration of ketamine

𝔎 Univ Kansas—ketamine treatment for ALS

𝔎 Takeda Pharm—depression tx, after ketamine therapy

𝔎 CaaMTech—combinations of serotonergic drugs

1/6
Celon Pharma—“Ketamine Composition for Use in a Method of Treatment of Depression by Pulmonary Administration”

–inhalable dry powder ketamine compositions

–dosage regimens for their use “in a cycle of administrations of sequences of single doses”

appft.uspto.gov/netacgi/nph-Pa…

2/6
University of Kansas—“Ketamine Treatment for Amyotrophic Lateral Sclerosis”

Covers use of ketamine to:

–extend life expectancy

–increase number of days of survival

–reduce rate of deterioration of body weight

Claims all found novel & inventive

patentscope.wipo.int/search/en/deta…

3/6
Read 6 tweets

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