New paper: Mice and Men have Covid brain damage
Mild respiratory SARS-CoV-2 infection can cause multi-lineage cellular dysregulation and myelin loss in the brain
Cancer therapy cognitive impairment and Covid have similar patterns of brain damage
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biorxiv.org/content/10.110…
Survivors of SARS-CoV-2 frequently experience lingering neurological symptoms: impairment in attention, concentration, speed of information processing and memory.
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This long-COVID cognitive syndrome shares many features with the syndrome of cancer therapy-related cognitive impairment (CRCI).
Neuroinflammation, and dysregulation of hippocampal neurogenesis is central to CRCI.
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Human brain tissue from 9 individuals with COVID-19 or SARS-CoV-2 infection exhibits prominent white matter-selective microglial reactivity.
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Taken together, the findings presented here illustrate striking similarities between neuropathophysiology after cancer therapy and after SARS-CoV-2 infection, that may contribute to lasting neurological symptoms following even mild SARS-CoV-2 infection.
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