Psychedelics making it today to the top of USA 🇺🇲 health institutions: @NIH
Joshua Gordon started emphasizing NIH's #mechanistic funding focus
4k attendees in 21 time zones 🌏🌎🌐
Franz Vollenweider 🇨🇭 👨🔬 summarizing history and neurobiology 🧠
Molecular mechanisms focused on 5HT2A receptor and downstream Glutamate release
Sophisticated psychological model summarized nicely in one slide 👍
Alpha power drop highlighted as most reliable brain signature of psychedelics.
Among others, I observed this in my own brain during ayahuasca EEG postdoc back in 2013 🌿🧠
Systemic model centered on thalamo-cortical connectivity
@AnnaCiaunica will enjoy seeing bodily self experiences included
Vollenweider concluding with recent model developed with @KatrinPreller 👩🔬 🇨🇭 Amazing work you two and team, so much effort for so long! 👏👏👏👏👏
Gabriella Gobbi now from @McGillNBPU speaking about translational issues, or how do 🐁🐒 ↔️🚶♀️🚶♂️research interelates
LSD shown to increase sociability in mice.
Ask ravers about it 😉
Optogenetic manipulation of prefrontal cortex 🐁 can inhibit psychedelic-induced sociability
Gobbi's recommendation seem to be low-micro dose therapeutic regimes, yet with psychotherapy. Thank you for the work @McGillNBPU lab!
Now @zenbrainest taking us into the fascinating nanometer scales of drug-receptor binding interactions
Fascinating drug-receptor binding maps evolving.
How do we make sense of this kind of data and the more simplistic focus on 5HT2A receptor? 🤔
320 GPCRs 🤯 Bryan Roth data blows my mind
Psilocin dopaminergic effects...
After all, would there be so much enthusiasm without good old reinforcing dopamine? 🤣
Now Clinton Canal with an important question...
Another way to frame it 🤣
Now Scott Thompson @sthom003 on more preclinical and mechanisms
What are 5HT2A receptors actually necessary for?
Now back to humans with @GitteKnudsen2 🇩🇰 with new in vivo imaging
5HT2A receptor downregulation
Watch out party and churchgoers...
Fewer receptors more mindfulness?
Mystical neurochemistry? Awesome lecture 🇩🇰 @GitteKnudsen2 👏👏👏👏👏
Rob Malenka: are 5HT2A receptors necessary AND sufficient?
Awesome panel, thank you all for the lectures today 💫
In a sense I've been looking forward for this kind of event for 15 years!
Lovely closing remark by Franz Vollenweider: these are not just pharmacological treatments. Listen the therapists as well!! 👏👏👏👏👏
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