Thread by @ee_schenberg

Psychedelics making it today to the top of USA 🇺🇲 health institutions: @NIH

Joshua Gordon started emphasizing NIH's #mechanistic funding focus

4k attendees in 21 time zones 🌏🌎🌐

Franz Vollenweider 🇨🇭 👨‍🔬 summarizing history and neurobiology 🧠

Molecular mechanisms focused on 5HT2A receptor and downstream Glutamate release

Sophisticated psychological model summarized nicely in one slide 👍

Alpha power drop highlighted as most reliable brain signature of psychedelics.

Among others, I observed this in my own brain during ayahuasca EEG postdoc back in 2013 🌿🧠

Systemic model centered on thalamo-cortical connectivity

@AnnaCiaunica will enjoy seeing bodily self experiences included

Vollenweider concluding with recent model developed with @KatrinPreller 👩‍🔬 🇨🇭 Amazing work you two and team, so much effort for so long! 👏👏👏👏👏

Gabriella Gobbi now from @McGillNBPU speaking about translational issues, or how do 🐁🐒 ↔️🚶‍♀️🚶‍♂️research interelates

LSD shown to increase sociability in mice.

Ask ravers about it 😉

Optogenetic manipulation of prefrontal cortex 🐁 can inhibit psychedelic-induced sociability

Gobbi's recommendation seem to be low-micro dose therapeutic regimes, yet with psychotherapy. Thank you for the work @McGillNBPU lab!

Now @zenbrainest taking us into the fascinating nanometer scales of drug-receptor binding interactions

Fascinating drug-receptor binding maps evolving.

How do we make sense of this kind of data and the more simplistic focus on 5HT2A receptor? 🤔

320 GPCRs 🤯 Bryan Roth data blows my mind

Psilocin dopaminergic effects...

After all, would there be so much enthusiasm without good old reinforcing dopamine? 🤣

Now Clinton Canal with an important question...

Another way to frame it 🤣

Now Scott Thompson @sthom003 on more preclinical and mechanisms

What are 5HT2A receptors actually necessary for?

Now back to humans with @GitteKnudsen2 🇩🇰 with new in vivo imaging

5HT2A receptor downregulation

Watch out party and churchgoers...

Fewer receptors more mindfulness?

Mystical neurochemistry? Awesome lecture 🇩🇰 @GitteKnudsen2 👏👏👏👏👏

Rob Malenka: are 5HT2A receptors necessary AND sufficient?

Awesome panel, thank you all for the lectures today 💫

In a sense I've been looking forward for this kind of event for 15 years!

Lovely closing remark by Franz Vollenweider: these are not just pharmacological treatments. Listen the therapists as well!! 👏👏👏👏👏

@threadreaderapp please compile