So many amazing teams, having trouble filling out my #RheumMadness bracket!
2021: I thought the tournament came down to clinical trials vs scientific discoveries
Spoiler alert: clinical trials won (😢)
2022: past vs present vs future?
🧵
Cells region: all about future implication
- NET: hot topic for a while now, but not yet ready for clinical utility
- Cytokine networks: may redefine how we classify rheumatic disease, though not anytime soon
CAR-T and Pim kinases: both cancer therapies that can be repurposed for rheumatic disease
Both many years away from routine clinical care, though CAR-T has been successful in severe SLE!
Animals region: bridging past and future
- Do ancient evolutionary advances (axolotl limbs) have a role in regenerative medicine?
- Do dinosaur skeletons teach us about SpA today?
- Can we improve human tx by studying dog physiology that has been around forever (gout, OA)?
Machines region:
- Predicting TNFi response, JIA subtypes: discovering new ways to use tech in rheum in future, but far from clinical utility
- DECT, PET in LVV: how to optimize tech already at our disposal for dx and monitoring in challenging cases
People region: all about NOW
- Repro health guide, TNFi in cord blood: how can we care for pregnant rheumatic disease patients better now?
- How do we interpret tests we already use all the time (ANA, MRI)?
Ultimately, this comes down to the #BlueRibbonPanel
❓Will they prioritize current clinical utility?
❓Will they take into consideration the historical context of current discoveries?
❓For future implications, is it about magnitude of impact or time to clinical applicability?
Any thoughts on how the Blue Ribbon Panel will decide?
Anyone willing to share their predictions/reasoning?
@DavidLeverenz @Nephro_Sparks @LisaCriscione @AUGarren
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