Guy Katz, MD Profile picture
Mar 21, 2022 8 tweets 4 min read Read on X
So many amazing teams, having trouble filling out my #RheumMadness bracket!

2021: I thought the tournament came down to clinical trials vs scientific discoveries

Spoiler alert: clinical trials won (😢)

2022: past vs present vs future?

🧵
Cells region: all about future implication
- NET: hot topic for a while now, but not yet ready for clinical utility
- Cytokine networks: may redefine how we classify rheumatic disease, though not anytime soon
CAR-T and Pim kinases: both cancer therapies that can be repurposed for rheumatic disease

Both many years away from routine clinical care, though CAR-T has been successful in severe SLE!
Animals region: bridging past and future
- Do ancient evolutionary advances (axolotl limbs) have a role in regenerative medicine?
- Do dinosaur skeletons teach us about SpA today?
- Can we improve human tx by studying dog physiology that has been around forever (gout, OA)?
Machines region:
- Predicting TNFi response, JIA subtypes: discovering new ways to use tech in rheum in future, but far from clinical utility
- DECT, PET in LVV: how to optimize tech already at our disposal for dx and monitoring in challenging cases
People region: all about NOW
- Repro health guide, TNFi in cord blood: how can we care for pregnant rheumatic disease patients better now?
- How do we interpret tests we already use all the time (ANA, MRI)?
Ultimately, this comes down to the #BlueRibbonPanel
❓Will they prioritize current clinical utility?
❓Will they take into consideration the historical context of current discoveries?
❓For future implications, is it about magnitude of impact or time to clinical applicability?
Any thoughts on how the Blue Ribbon Panel will decide?

Anyone willing to share their predictions/reasoning?

@DavidLeverenz @Nephro_Sparks @LisaCriscione @AUGarren

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More from @GuyKatzMD

Mar 25, 2021
Still can't get over how good the #RheumMadness scouting reports are.

Common themes:
✅Most teams are convinced they will win their first round match-up (🤔)
✅Everyone is worried about AAV/SLE teams

Are we being blinded by the bright and shiny AAV/SLE trials?

I say yes.

🧵
First, let's acknowledge that these trials (BLISS-LN, TULIP, PEXIVAS, ADVOCATE) are amazing and definitely worthy competitors. But clinical trials aren't new in #Rheumatology and the other teams offer so much to our field.
IgG4-RD Classification Criteria:

✅Disease many in our field don't understand
✅Describe common + rare manifestations
✅Emphasize IgG4-RD 🆚 mimickers

Think it's too rare to win? We don't even know prevalence (likely under-recognized)!

Hence the criteria...
Read 18 tweets

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