Punishi Parekh Profile picture
MBBS MD Pediatrics @KEMHOSPITAL | Postdoc @UMNmedschool in Epidemiology & Clinical Research | passionate about academics | #Pediatrics #Medtwitter

Sep 4, 2022, 10 tweets

A full term 2.2kg baby with this clinical picture !

Diagnosis?
Classical triad?

#MedTwitter
#Pediatrics
#neonatal

Congenital Rubella syndrome it is !!

Pathogenesis:

⏩Feto maternal transmission occurs hematogenously after maternal viremia
⏩After infecting the placenta, the virus spreads in fetus’ vascular system
⏩Causes cytopathic damage to blood vessels and ischemia in affected organs

⏩Highest risk of transmission in first 10 weeks of gestation
⏩Cardiac and eye defects before 8 weeks
⏩Hearing loss uptil 18 weeks

Clinical manifestations:

Ophthalmological findings:

⏩Blueberry muffin lesions
⏩Celery stalk metaphysis

Cardiac manifestation:
PDA
Branch pulmonary artery stenosis (aka peripheral pulmonary stenosis)

Diagnosis of CRS

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