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Stephen V Liu, MD Profile picture
Stephen V Liu, MD
@StephenVLiu
Director of Thoracic Oncology & Developmental Therapeutics @Georgetown @LombardiCancer; Host @IASLC Podcast; Chair #DCLung24 #TexasLung24 #HereWeGo

Sep 11, 2022, 5 tweets

Dr. @marinagarassino presents 5-year efficacy and safety update of KEYNOTE-189 (1L carboplatin plus pemetrexed +- pembrolizumab in non-squamous NSCLC) #ESMO22

KEYNOTE 189 is our SOC and has shown a consistent benefit including improving OS even with a crossover rate of 57%. #ESMO22

KEYNOTE 189 shows sustained OS benefit with longer follow up and a 5y OS rate of 18.4% with an OS HR of 0.60. Better PFS and OS also observed. Benefit across PDL1 strata. No new safety signals . #ESMO22

Here are data from patients who completed the 35 planned cycles of pembrolizumab on KEYNOTE 189. In that group, RR 86% and mDOR 58m with a 72% 3y OS rate. Note 40% alive without PD or subsequent therapy. Looking forward to more details on this group. #ESMO22

Longer follow up confirms survival benefit of chemo-immunotherapy in NSCLC. Important update from #ESMO22 by @marinagarassino

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