Best way to recognize pathological/neoplastic immunophenotypic changes is having a good grip on immunophynotypic variations in reactive/regenerative conditions… summarizing #FlowICCS22 plenary session 3 here👇🏻 🧵1/ #hemepath
Normal granulocytic maturation patterns…. Plots follow maturation from promyelocyte (*) to neutrophils #flowiccs22 #hemepath 2/
Here are phenotypic changes post GCSF therapy compared to Normal…. Don’t over-interpret this pattern as abnormal myeloid maturation #flowiccs22 #hemepath 3/ promyelocyte (*) to neutrophil
How about complete absence of antigens?
1. absence of CD14 /CD16: think #PNH
2. Isolated absence of CD38: think #daratumumab (anti-cd38 for #myeloma)
#flowiccs22 #hemepath 4/
Be aware of CD56 expression on normal myeloid progenitors, PDCs, and maturing myeloid and monocytic cells of individuals with #DownSyndrome don’t over-interpret as neoplastic changes #flowiccs22 #hemepath 5/
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