A MUST: “mRNA as a medicine” Melissa Moore, MD leads us through drug development, from Penicillin to MABs #KidneyWk @ASNKidney
More than 100 monoclonal antibodies have been approved by @US_FDA but they have multiple limitations #KidneyWk @ASNKidney
Proteins have been used as medicine, but only a small proportion can be used, whereas mRNA enable the body to produce “own medicine” #KidneyWk @ASNKidney
How does mRNA compares to regular medications? #KidneyWk @ASNKidney
Three different fields should be addressed to use mRNA as medicine, a work that has taken 60 years since the discovery of mRNA #KidneyWk @ASNKidney
One of the key issues is to have the right “delivery” system: not virus, no “naked” mRNA #KidneyWk @ASNKidney
Lipid nanoparticles were found to be the answer for this objective #KidneyWk @ASNKidney
All this concepts and research has lead to #MODERNA COVID-19 vaccine development #KidneyWk @ASNKidney
THE FUTURE: #MODERNA investigational pipeline is AMAZING, different targets as cancer or the so called orphan diseases #KidneyWk @ASNKidney
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