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Feb 13, 2023, 8 tweets

What is Buttonhole sign?

Buttonhole sign

In type 1 neurofibromatosis (Von-Recklinghausen's disease)

👉neurofibromas can be invaginated with the tip of index finger back into the subcutis and again reappear after release of pressure.

Buttonhole sign

Other condition where one can find positive buttonhole sign are

anetoderma

dermatofibroma.

Dermatofibroma

👉 commonly occurring cutaneous entity usually centered within the skin's dermis

👉 benign fibrous histiocytomas of the skin, superficial/cutaneous benign fibrous histiocytomas, or common fibrous histiocytoma

Anetoderma, also known as macular atrophy

👉 uncommon disorder of elastic tissue

👉 clinically characterized by wrinkled and atrophic depressions or saccular outpouchings of the skin

👉 these may herniate upon digital pressure

Von-Recklinghausen's disease

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