🛌Fantastic presentation by Dr. Isabel Spriet on #antifungal dosing, which included several patient case discussions! #ECCMID2023
- Major clinical uses of antifungals
- Focus is on invasive fungal infections
Standard dosing of antifungals are based on patient PK, fungal pathogen PD, and ideal PK-PD targets... #ECCMID2023
Translational research model for antifungal drug development involves pre-clinical PK-PD target determination followed by clinical trials... #ECCMID2023
Established PK-PD indices for antifungal agents... #ECCMID2023
Dose selection of new antimicrobials based on PK-PD targets... #ECCMID2023
Regulatory-approved antifungal standard dosing... #ECCMID2023
But how well does standard dosing apply to patients in clinical practice? #ECCMID2023
A 4-step framework for developing optimized doses.
1. Exposure to standard dosing - Are PK-PD targets attained?
2. Modeling of exposure
3. Dosing simulations
4. Prospective clinical validation
#ECCMID2023
TDM for mold-active azoles... is it the solution? #ECCMID2023
Traditional TDM cycle may not work for all patients. #ECCMID2023
Model-informed precision dosing may be needed for some patients! #ECCMID2023
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