🛌Fantastic presentation by Dr. Isabel Spriet on #antifungal dosing, which included several patient case discussions! #ECCMID2023
- Major clinical uses of antifungals
- Focus is on invasive fungal infections Image
Standard dosing of antifungals are based on patient PK, fungal pathogen PD, and ideal PK-PD targets... #ECCMID2023 Image
Translational research model for antifungal drug development involves pre-clinical PK-PD target determination followed by clinical trials... #ECCMID2023 Image
Established PK-PD indices for antifungal agents... #ECCMID2023 Image
Dose selection of new antimicrobials based on PK-PD targets... #ECCMID2023 Image
Regulatory-approved antifungal standard dosing... #ECCMID2023 Image
But how well does standard dosing apply to patients in clinical practice? #ECCMID2023 ImageImage
A 4-step framework for developing optimized doses.
1. Exposure to standard dosing - Are PK-PD targets attained?
2. Modeling of exposure
3. Dosing simulations
4. Prospective clinical validation
#ECCMID2023 Image
TDM for mold-active azoles... is it the solution? #ECCMID2023 Image
Traditional TDM cycle may not work for all patients. #ECCMID2023 ImageImage
Model-informed precision dosing may be needed for some patients! #ECCMID2023 Image

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Keep Current with Alireza FakhriRavari, PharmD, BCPS, BCIDP, AAHIVP

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More from @LordAlirezaF

Oct 14, 2023
📃Upcoming Guidelines Spoilers #IDWeek2023
First-ever IDSA guidelines for complicated Urinary Tract Infection (cUTI) #UTI Image
📃IDSA guidelines for cUTI #IDWeek2023 #UTI
- New definition of cUTI
– Includes all febrile UTI, pyelo, CAUTI, bacteremic UTI Image
📃IDSA guidelines for cUTI #IDWeek2023 #UTI
- Selection of empiric antibiotic therapy for cUTI
– Four-step process: Review
(1) severity of illness,
(2) risk factors for resistant organisms,
(3) patient factors, and
(4) antibiogram (only if septic)
Image
Image
Read 12 tweets
Apr 16, 2023
👨‍⚕️Very nice session on issues of complicated UTIs by Dr. Aurelien Dinh. #ECCMID2023
- It's believed that cUTI is more difficult to treat
- Maybe higher rate of resistance
- Need higher dosage or prolonged treatment? ImageImage
Modern definitions of cUTIs... #ECCMID2023 Image
Does "complicated" definition apply to all kinds of UTIs? Uncomplicated pyelonephritis?? 🤨 #ECCMID2023 Image
Read 10 tweets

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