1. Simple policy like 'hygiene and pasteurization' doubled the human lifespan after 1889, stopping constant CoV outbreaks from milk.
Simple policy like 'quarantine, isolation, N95 and international cooperation' ended SARS-CoV-1.
We can end CoV-2. Don't halve the human lifespan.
@ilonamotto @RealCheckMarker 93. What I see is such analysis: Creative yet generic, abstract and not reflecting existing law, policymaking, and SARS-CoV-2 literature—WHO IHR 2005 as most relevant example. We could do better as political scientists, systems scholars, parents or just as public-facing scholars.
95. One fundamental problem: IPCC and mainstream science ignore uncomfortable knowledge (@SFuntowicz PNS). Undesirable social tipping points (@ilonamotto) or positive feedback structures like aerosols are ignored in favor of politically acceptable stories. science.org/doi/10.1126/sc…
@ilonamotto @OECD_ENV 97. Why do I criticize X? (Not just @W_Lucht complained) Because I hold climate and systems scientists to higher standard. Few others enjoy similar privileges of education.
Because we think decades ahead, vital in a pandemic. Because we can and should develop workable solutions.
106. Prion disease is considered THE RPD prototype, but over the past 20 years epidemiological reports and various encephalitis-mediating antibodies have led to a growing recognition of other encephalopathies as potential causes of rapid cognitive decline. nature.com/articles/s4158…
@RealCheckMarker @kali0x2a 109. I now think SARS-CoV-2 will lead to progress in prion science, but in the meantime check out viroids. Life begins with single strings of RNA. This is as close to magic as it gets.
Proposed mechanism: 👇 shoutout to @dbdugger, who can administer MoCA tests; I hear it's even free for students or higher ed staff. Much more research needed. As long as our "Living with SARS-CoV infections" clownshow continues, the virus will outmutate and outpace humans. Enjoy,
@dbdugger 111. Brain-derived neurotrophic factor (BDNF) is key to neuron survival and growth. Maternal serum BDNF decreased in COVID+ pregnant women, unlike umbilical cord BDNF. Fetal blood-brain barrier may protect the fetus from inflammation and maternal hypoxia. https://t.co/ZkfqvaXTTmeuropeanreview.org/article/31807
@mtosterholm 113. Long-term neurodevelopmental sequelae are seen in neonates after in utero SARS-CoV-2 exposure. Report of two neonates after mid-term maternal infection who displayed early-onset (d1) seizures, acquired microcephaly and significant developmental delay. publications.aap.org/pediatrics/art…
114. In HIV, small trans activator proteins (Tat, Nef, Rev) modulate transcription of cellular genes. Likewise, in SARS-CoV-2 Orf8 acts as histone mimic disrupting chromatic structure with many epigenetic and immune modulator changes. - We shared all this. https://t.co/MyOis35txropastpublishers.com/open-access-ar…
121. While some draw spider diagrams (🥴), we know: "As SARS-CoV-2 infects pAPCs including DCs, macrophages, B cells, and non-p APCs this suppression of MHC II has the potential to dramatically decrease the activation of CD4+ T cells in COVID-19 patients." https://t.co/xR8un0YGVwbiorxiv.org/content/10.110…
122. If you do spider diagrams, connect everything to everything, incl. all elements in the second column to each other. Dysbiosis and microbial dislocation are feeling lonely🤣
Learn from HIV science. You are not helping COVID survivors by not following evidence based medicine.
123. Thread of pediatric COVID-19 literature. You can add arbitrarily more, eg Systemic Inflammation and Microbial Translocation Are Characteristic Features of SARS-CoV-2-Related Multisystem Inflammatory Syndrome in Children (MIS-C). 2021.
All well known. https://t.co/VCDKxK968H
124. 2021 study from India: "MIS-C and COVID-19 are characterized by systemic inflammation and microbial translocation, 2 processes that may play a pivotal role in disease pathogenesis, including multi-organ involvement and dysfunction in these children." academic.oup.com/ofid/article/8…
132. “Adopting at least two prevention measures during rooming-in resulted in a rate of mother-to-child infection of 1.0% (95%CI: 0.3–1.7%). Low rate of perinatal SARS-CoV-2 infection supports rooming-in and preventive measures.” nature.com/articles/s4159…
135. As political scientist, a hint: @SAHIVSoc offers good materials. There is even a dedicated UN programme to learn from, present in many member states @UNAIDS @UNAIDS_CN @UNAIDSBrasil. You will need international cooperation and the same for SARS-CoV-2. sahivsoc.org/Guidelines/Mod…
@SAHIVSoc @UNAIDS @UNAIDS_CN @UNAIDSBrasil 136. Here one of the mechanisms SARS-CoV-2 uses to inactivate CD4+. It's no coincidence that it behaves like HIV-1 or Ebola virus. They share structural and sequence similarity in various proteins even beyond the much-discussed spike S1, as did SARS-CoV-1. https://t.co/gipBL1ISjpbiorxiv.org/content/10.110…
@SAHIVSoc @UNAIDS @UNAIDS_CN @UNAIDSBrasil 137. It's a syndemic and needs to be analyzed as such. SARS-CoV-2 acts as latency reversal agent (LRA) in HIV+ patients, notably on PLWH with HAND diagnosis. The paper is good but wrong: SARS-CoV absolutely does form viral reservoirs and chronic infection. https://t.co/ilgUxD4KPKmdpi.com/1999-4915/15/5…
138. C3 rs1047286 or rs2230199 coding SNPs were found in 60 % of Deceased (n=25) (67 % of Deceased Males) and 31 % of Survivors (n=105, p = 0.012) (rs2230199 in 25 % of Survivor Males).
rs2230199 is highest in Caucasians (18 %) and lowest in Asians (1 %). sciencedirect.com/science/articl…
142. Silvio Berlusconi died 86 yo after COVID-19 in 2020. He now contributes to the literature on outcomes of early treatment of SARS-CoV-2 infection in patients with haematological disorders, here rare blood cancer chronic myelomonocytic leukaemia (CMML). mdpi.com/2673-6357/4/2/…
143. Three years survival are respectable for a man of Berlusconi's age, a testament to Milano's medical excellence. To understand context, read the threads we shared on SARS-CoV-2 and non-Hodgkin lymphoma (NHL) or chronic lymphocytic leukaemia (CLL). onlinelibrary.wiley.com/doi/full/10.11…
@RealCheckMarker 147. Modeling of SARS-CoV-2 open reading frames (Orfs) liebertpub.com/doi/full/10.10…
@RealCheckMarker 148. SARS-CoV-2 evolved unique changes to manipulate autophagy and endocytic pathways to help viral replication and downregulate host innate immunity response, promoting its survival. Orf3a and Orf10 work together; M and Orf10 localize to the mitochondria. https://t.co/wnSLYK8DzXmdpi.com/1422-0067/24/9…
153. The days of Arctic summer sea ice are numbered (by thermodynamics not us, so there's little you can do about it -- but if enough people listen and act, we may be able to slow things down significantly). Zoom in here, the entire Arctic is swiss cheese. https://t.co/REJ9btGiRNworldview.earthdata.nasa.gov/?v=-3291114.51…
@JessicaLexicus 160. 16th Century immunoglobulins and nucleocapsid peptides detected, indicating a HCoV different from modern coronaviruses and SARS-CoV-2, an old HCoV with no known modern representative. Zoonosis suspected from deer, dogs, swine, cattle. It's unknown whether they visited Wuhan.
161. What distinguishes SARS-CoV from other coronaviruses? MDs, patients, policymakers won't understand the COVID-19 pandemic until they read science because the basics are too counterintuitive to cover in conversation. Great ACE2 overview: @GOuditResearch cell.com/cell/fulltext/…
@HugonetX @Mike_Honey_ 164. Incredible study worth reading: 21 autopsies in Argentina Jan to Aug 2022. Ten deaths after hospitalization, 11 non-hospitalized. 7 were unvaccinated, 13 COVID-19 vaccinated in different formulations. 5 SARS-CoV-2 reinfections within past 6–12 months. frontiersin.org/articles/10.33…
165. SARS-CoV-2 RNA (for ORF1ab, N) was found in all tissues and 47 out of 100 tissue samples: 13/21 in the lung, 7/21 heart, 9/21 liver, 8/21 kidney, 10/16 in the small intestine tissue. (working link 👇) ncbi.nlm.nih.gov/pmc/articles/P…
166. Viral load (in viral copies/mL for the Orf1ab and N gene) was highest in the lung (4,400 and 6,200) with VL ranging from 101 to an incredible 114 million.
Median VL was lower in liver (520 and 290), heart (6,100 and 830), kidney (470 and 600), small intestine (980 and 320).
67. The absence of SARS-CoV-2 RNA in tissue tested did not necessarily correlate with the absence of viable SARS-CoV-2. The presence of viral RNA did not necessarily imply the presence of infective viral particles.
Also corpses can be infectious after months in an earth grave.
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@threadreaderapp unroll, second try
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