How to read an HLA report?
A thread 🧵✍️on understating HLA typing for BMT
Key slides from my talk at #ISBMT Annual Meeting
(1/7) @IsbmtU @ASTCT @ASTCT_Journal @ISMPOofficial @ishbtHematology
➡️Usually, a high resolution HLA typing is done for finding a donor for BMT.
➡️It employs Next generation sequencing.
As a result the report comes in form of a combination of many letters and numbers.
This slides explains 4 major fields of HLA report
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The last two suffixes in HLA nomenclature, in this case 02: 14, are not used for HLA matching in routine clinical practice.
Their interpretation is as follows.
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What do we understand by "low resolution typing"?
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and what is a high resolution typing?
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The last point is a bit complex:- it is direction of HLA mismatch.
➡️A mismatch in graft vs host direction increases risk of GVHD
➡️A mismatch in host vs graft direction increases risk of graft loss.
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Ending this thread🧵 with tributes to these 3 eminent scientists who discovered HLA and revolutionized the field of immunology and BMT.
They were awarded Nobel prize for medicine in 1980.
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