How to read an HLA report?
A thread 🧵✍️on understating HLA typing for BMT

Key slides from my talk at #ISBMT Annual Meeting
(1/7) @IsbmtU @ASTCT @ASTCT_Journal @ISMPOofficial @ishbtHematology ➡️Usually, a high resolution HLA typing is done for finding a donor for BMT.
➡️It employs Next generation sequencing.
As a result the report comes in form of a combination of many letters and numbers.
This slides explains 4 major fields of HLA report
(2/7)

A chemo-port is always an intriguing device for people not trained in the field of Oncology.
It is simple implantable device which is used to deliver IV therapies of various kinds with ease and safety to a patient
It looks just like a mini stethoscope :) 🩺 (1/n) A chemo-port has 3 parts
1- A well/chamber ( an area where a special Huber needle is inserted and drug is delivered)
2- A diaphragm ( usually self sealing thick silicon membrane)
3- A sialistic tubing which is inserted in a large cervico-thoracic vein (2/n)

1- TP53 a mediator of stress response and guards the genome from stress related changes of various kind 2- TP 53 mutation status in various tumors. The mutated allele frequencies are higher than we expect them to be