Dr Ivor Douglas discussing pathophysiology of IV fluids and vasopressors in #sepsis
#ATS2023
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Too much or too little fluids can have consequences.
What is the optimal range for fluids?
Excess fluid balance (> 5L in 1st day) is associated with increased mortality
What about vasopressors?
⛔️ Caution of microcirculatory complications
⛔️ vasopressors can have immunomodulating effects when titrated up
We always try to optimize macrocirculation in sepsis but more focus needed to assess microcirculation
👇🏻 effects of sepsis resuscitation on microcirculation
Extravasation rate with low dose vasopressors via PIV is low in #CLOVERS trial
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